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TitleMining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 11, Page 1620-1626, Year 2020
Publish dateJun 18, 2019 (structure data deposition date)
AuthorsHenderson, S.H. / Sorrell, F. / Bennett, J. / Hanley, M.T. / Robinson, S. / Hopkins Navratilova, I. / Elkins, J.M. / Ward, S.E.
External linksAcs Med. Chem. Lett. / PubMed:32832032
MethodsX-ray diffraction
Resolution2.38 Å
Structure data

PDB-6s1i:
Crystal Structure of DYRK1A with small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-KR8:
~{N}-methyl-~{N}-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / catalytic domain / phosphorylated

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