登録情報 | データベース: PDB / ID: 6okm |
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タイトル | Human OX40R (TNFRSF4) bound to Fab 3C8 |
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要素 | - Fab 3C8 Heavy Chain
- Fab 3C8 light chain
- Tumor necrosis factor receptor superfamily member 4
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キーワード | IMMUNE SYSTEM / OX40 / TNFRSF4 / Fab / receptor |
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機能・相同性 | 機能・相同性情報
tumor necrosis factor receptor activity / TNFs bind their physiological receptors / positive regulation of immunoglobulin production / T cell proliferation / positive regulation of B cell proliferation / negative regulation of DNA-binding transcription factor activity / virus receptor activity / inflammatory response / immune response / external side of plasma membrane ...tumor necrosis factor receptor activity / TNFs bind their physiological receptors / positive regulation of immunoglobulin production / T cell proliferation / positive regulation of B cell proliferation / negative regulation of DNA-binding transcription factor activity / virus receptor activity / inflammatory response / immune response / external side of plasma membrane / negative regulation of DNA-templated transcription / cell surface / plasma membrane類似検索 - 分子機能 Tumour necrosis factor receptor 4 / Tumour necrosis factor receptor 4, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Putative ephrin-receptor like / Immunoglobulins / Immunoglobulin-like ...Tumour necrosis factor receptor 4 / Tumour necrosis factor receptor 4, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Putative ephrin-receptor like / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Tumor necrosis factor receptor superfamily member 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Boenig, G. / Ultsch, M.H. / Harris, S.F. |
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引用 | ジャーナル: Mabs / 年: 2019 タイトル: Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members. 著者: Yang, Y. / Yeh, S.H. / Madireddi, S. / Matochko, W.L. / Gu, C. / Pacheco Sanchez, P. / Ultsch, M. / De Leon Boenig, G. / Harris, S.F. / Leonard, B. / Scales, S.J. / Zhu, J.W. / Christensen, E. ...著者: Yang, Y. / Yeh, S.H. / Madireddi, S. / Matochko, W.L. / Gu, C. / Pacheco Sanchez, P. / Ultsch, M. / De Leon Boenig, G. / Harris, S.F. / Leonard, B. / Scales, S.J. / Zhu, J.W. / Christensen, E. / Hang, J.Q. / Brezski, R.J. / Marsters, S. / Ashkenazi, A. / Sukumaran, S. / Chiu, H. / Cubas, R. / Kim, J.M. / Lazar, G.A. |
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履歴 | 登録 | 2019年4月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年8月28日 | Provider: repository / タイプ: Initial release |
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