Entry | Database: PDB / ID: 6g4y |
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Title | Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a |
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Components | Mitogen-activated protein kinase kinase kinase 14 |
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Keywords | TRANSFERASE / PROTEIN SERINE/THREONINE KINASE / NF-KAPPAB / MAP3K14 |
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Function / homology | Function and homology information
CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / canonical NF-kappaB signal transduction / cellular response to mechanical stimulus ...CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / canonical NF-kappaB signal transduction / cellular response to mechanical stimulus / fibrillar center / defense response to virus / protein kinase activity / immune response / protein serine kinase activity / protein serine/threonine kinase activity / nucleoplasm / ATP binding / cytosolSimilarity search - Function Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain ...Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.65 Å |
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Authors | Hole, A.J. / Hymowitz, S.G. / McEwan, P.A. |
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Citation | Journal: J. Med. Chem. / Year: 2018 Title: Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. Authors: Blaquiere, N. / Castanedo, G.M. / Burch, J.D. / Berezhkovskiy, L.M. / Brightbill, H. / Brown, S. / Chan, C. / Chiang, P.C. / Crawford, J.J. / Dong, T. / Fan, P. / Feng, J. / Ghilardi, N. / ...Authors: Blaquiere, N. / Castanedo, G.M. / Burch, J.D. / Berezhkovskiy, L.M. / Brightbill, H. / Brown, S. / Chan, C. / Chiang, P.C. / Crawford, J.J. / Dong, T. / Fan, P. / Feng, J. / Ghilardi, N. / Godemann, R. / Gogol, E. / Grabbe, A. / Hole, A.J. / Hu, B. / Hymowitz, S.G. / Alaoui Ismaili, M.H. / Le, H. / Lee, P. / Lee, W. / Lin, X. / Liu, N. / McEwan, P.A. / McKenzie, B. / Silvestre, H.L. / Suto, E. / Sujatha-Bhaskar, S. / Wu, G. / Wu, L.C. / Zhang, Y. / Zhong, Z. / Staben, S.T. |
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History | Deposition | Mar 28, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 4, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 1, 2018 | Group: Data collection / Database references / Category: citation / citation_author / Item: _citation.title |
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Revision 1.2 | Aug 22, 2018 | Group: Data collection / Database references / Structure summary Category: citation / struct Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _struct.title |
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Revision 1.3 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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