登録情報 | データベース: PDB / ID: 6n9n |
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タイトル | Crystal structure of murine GSDMD |
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要素 | Gasdermin-D |
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キーワード | IMMUNE SYSTEM / Pyroptosis / gasdermin D / inflammasome / autoinhibition |
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機能・相同性 | 機能・相同性情報
Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / pore complex assembly / : / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / phosphatidic acid binding ...Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / pore complex assembly / : / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / phosphatidic acid binding / phosphatidylinositol-4-phosphate binding / phosphatidylserine binding / pyroptotic inflammatory response / protein secretion / phosphatidylinositol-4,5-bisphosphate binding / Neutrophil degranulation / positive regulation of interleukin-1 beta production / mitochondrial membrane / protein homooligomerization / positive regulation of inflammatory response / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / innate immune response / extracellular space / nucleoplasm / plasma membrane / cytosol類似検索 - 分子機能 Gasdermin, PUB domain / Gasdermin PUB domain / Gasdermin, pore forming domain / Gasdermin pore forming domain類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å |
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データ登録者 | Liu, Z. / Wang, C. / Yang, J. / Xiao, T.S. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | GM127609 | 米国 | National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | AR069908 | 米国 |
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引用 | ジャーナル: Immunity / 年: 2019 タイトル: Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. 著者: Liu, Z. / Wang, C. / Yang, J. / Zhou, B. / Yang, R. / Ramachandran, R. / Abbott, D.W. / Xiao, T.S. |
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履歴 | 登録 | 2018年12月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年6月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年7月31日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first |
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改定 1.2 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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