Entry | Database: PDB / ID: 6n9o |
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Title | Crystal structure of human GSDMD |
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Components | Gasdermin-D |
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Keywords | IMMUNE SYSTEM / Pyroptosis / gasdermin D / inflammasome / autoinhibition |
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Function / homology | Function and homology information
pore complex assembly / : / Release of apoptotic factors from the mitochondria / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / Regulation of TLR by endogenous ligand / phosphatidic acid binding / Interleukin-1 processing / phosphatidylinositol-4-phosphate binding ...pore complex assembly / : / Release of apoptotic factors from the mitochondria / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / Regulation of TLR by endogenous ligand / phosphatidic acid binding / Interleukin-1 processing / phosphatidylinositol-4-phosphate binding / phosphatidylserine binding / pyroptotic inflammatory response / protein secretion / Pyroptosis / Purinergic signaling in leishmaniasis infection / phosphatidylinositol-4,5-bisphosphate binding / positive regulation of interleukin-1 beta production / mitochondrial membrane / protein homooligomerization / positive regulation of inflammatory response / specific granule lumen / tertiary granule lumen / defense response to Gram-negative bacterium / ficolin-1-rich granule lumen / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / innate immune response / Neutrophil degranulation / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane / cytosolSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å |
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Authors | Liu, Z. / Wang, C. / Yang, J. / Xiao, T.S. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | GM127609 | United States | National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | AR069908 | United States |
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Citation | Journal: Immunity / Year: 2019 Title: Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Authors: Liu, Z. / Wang, C. / Yang, J. / Zhou, B. / Yang, R. / Ramachandran, R. / Abbott, D.W. / Xiao, T.S. |
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History | Deposition | Dec 3, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jun 5, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 31, 2019 | Group: Data collection / Database references / Category: citation Item: _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first |
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Revision 1.2 | Dec 11, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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