Entry | Database: PDB / ID: 6ao3 |
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Title | Crystal structure of the murine gasdermin D C-terminal domain |
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Components | Gasdermin-D |
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Keywords | IMMUNE SYSTEM / Inflammasome / pyroptosis / gasdermin D / autoinhibition / Salmonella infection |
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Function / homology | Function and homology information
Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / pore complex assembly / : / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / phosphatidic acid binding ...Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / pore complex assembly / : / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / phosphatidic acid binding / phosphatidylinositol-4-phosphate binding / phosphatidylserine binding / pyroptotic inflammatory response / protein secretion / phosphatidylinositol-4,5-bisphosphate binding / Neutrophil degranulation / positive regulation of interleukin-1 beta production / mitochondrial membrane / protein homooligomerization / positive regulation of inflammatory response / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / innate immune response / extracellular space / nucleoplasm / plasma membrane / cytosolSimilarity search - Function |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 1.76 Å |
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Authors | Liu, Z. / Wang, C. / Yang, J. / Xiao, T.S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | AR069908 | United States |
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Citation | Journal: Structure / Year: 2018 Title: Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition. Authors: Liu, Z. / Wang, C. / Rathkey, J.K. / Yang, J. / Dubyak, G.R. / Abbott, D.W. / Xiao, T.S. |
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History | Deposition | Aug 15, 2017 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 11, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 9, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | Dec 11, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Mar 13, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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