- PDB-6hoh: Structure of VPS34 LIR motif (S249E) bound to GABARAP -
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Basic information
Entry
Database: PDB / ID: 6hoh
Title
Structure of VPS34 LIR motif (S249E) bound to GABARAP
Components
Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein
Keywords
SIGNALING PROTEIN / Autophagy / ATG8 / LIR
Function / homology
Function and homology information
Toll Like Receptor 9 (TLR9) Cascade / protein lipidation / Synthesis of PIPs at the late endosome membrane / phosphatidylinositol 3-kinase complex, class III / Synthesis of PIPs at the early endosome membrane / phosphatidylinositol 3-kinase complex, class III, type II / phosphatidylinositol 3-kinase complex, class III, type I / positive regulation of protein K48-linked ubiquitination / positive regulation by host of viral genome replication / Synthesis of PIPs at the Golgi membrane ...Toll Like Receptor 9 (TLR9) Cascade / protein lipidation / Synthesis of PIPs at the late endosome membrane / phosphatidylinositol 3-kinase complex, class III / Synthesis of PIPs at the early endosome membrane / phosphatidylinositol 3-kinase complex, class III, type II / phosphatidylinositol 3-kinase complex, class III, type I / positive regulation of protein K48-linked ubiquitination / positive regulation by host of viral genome replication / Synthesis of PIPs at the Golgi membrane / regulation of Rac protein signal transduction / phosphatidylinositol kinase activity / protein localization to phagophore assembly site / GABA receptor binding / protein targeting to lysosome / early endosome to late endosome transport / cellular response to nitrogen starvation / phosphatidylethanolamine binding / Translation of Replicase and Assembly of the Replication Transcription Complex / phagophore assembly site / TBC/RABGAPs / microtubule associated complex / autolysosome / phosphatidylinositol 3-kinase / phosphatidylinositol-3-phosphate biosynthetic process / Macroautophagy / 1-phosphatidylinositol-3-kinase activity / beta-tubulin binding / axoneme / phosphatidylinositol-mediated signaling / autophagosome membrane / phosphatidylinositol phosphate biosynthetic process / autophagosome maturation / autophagosome assembly / extrinsic apoptotic signaling pathway via death domain receptors / PI3K Cascade / smooth endoplasmic reticulum / RHO GTPases Activate NADPH Oxidases / autophagosome / regulation of macroautophagy / protein targeting / cellular response to glucose starvation / sperm midpiece / regulation of cytokinesis / regulation of autophagy / macroautophagy / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / autophagy / microtubule cytoskeleton organization / endocytosis / phagocytic vesicle membrane / peroxisome / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein transport / actin cytoskeleton / late endosome / kinase activity / Translation of Replicase and Assembly of the Replication Transcription Complex / midbody / cytoplasmic vesicle / microtubule binding / chemical synaptic transmission / microtubule / lysosome / protein kinase activity / endosome / cell cycle / phosphorylation / cell division / Golgi membrane / ubiquitin protein ligase binding / synapse / SARS-CoV-2 activates/modulates innate and adaptive immune responses / ATP binding / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function
B: Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein C: Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein
D: Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein