Entry Database : PDB / ID : 6ejx Structure visualization Downloads & linksTitle The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function ComponentsPlatelet glycoprotein Ib alpha chain Details Keywords BLOOD CLOTTING / Gp1balpha / Mac-1Function / homology Function and homology informationFunction Domain/homology Component
GP1b-IX-V activation signalling / : / Platelet Adhesion to exposed collagen / Platelet Aggregation (Plug Formation) / Intrinsic Pathway of Fibrin Clot Formation / hemostasis / plasma membrane => GO:0005886 / fibrinolysis / extracellular matrix / cell morphogenesis ... GP1b-IX-V activation signalling / : / Platelet Adhesion to exposed collagen / Platelet Aggregation (Plug Formation) / Intrinsic Pathway of Fibrin Clot Formation / hemostasis / plasma membrane => GO:0005886 / fibrinolysis / extracellular matrix / cell morphogenesis / platelet aggregation / blood coagulation / cell adhesion / extracellular space / membrane / plasma membrane Similarity search - Function Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat ... Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Emsley, J. / Saleem, M. CitationJournal : Blood Adv / Year : 2019Title : Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.Authors : Morgan, J. / Saleem, M. / Ng, R. / Armstrong, C. / Wong, S.S. / Caulton, S.G. / Fickling, A. / Williams, H.E.L. / Munday, A.D. / Lopez, J.A. / Searle, M.S. / Emsley, J. History Deposition Sep 24, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 24, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Nov 6, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 17, 2024 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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