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Structure paper

TitleStructural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.
Journal, issue, pagesBlood Adv, Vol. 3, Page 1450-1459, Year 2019
Publish dateSep 24, 2017 (structure data deposition date)
AuthorsMorgan, J. / Saleem, M. / Ng, R. / Armstrong, C. / Wong, S.S. / Caulton, S.G. / Fickling, A. / Williams, H.E.L. / Munday, A.D. / Lopez, J.A. ...Morgan, J. / Saleem, M. / Ng, R. / Armstrong, C. / Wong, S.S. / Caulton, S.G. / Fickling, A. / Williams, H.E.L. / Munday, A.D. / Lopez, J.A. / Searle, M.S. / Emsley, J.
External linksBlood Adv / PubMed:31053572
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6ejx:
The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-IMD:
IMIDAZOLE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-POL:
N-PROPANOL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsBLOOD CLOTTING / Gp1balpha / Mac-1

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