Entry Database : PDB / ID : 6d94 Structure visualization Downloads & linksTitle Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1 ComponentsMediator of RNA polymerase II transcription subunit 1 Peroxisome proliferator-activated receptor gamma DetailsKeywords dna binding protein/AGONIST / Nuclear receptor / Transcription factor / Super agonist / Ligand binding domain / Coactivator / MED1 / DNA BINDING PROTEIN / dna binding protein-AGONIST complexFunction / homology Function and homology informationFunction Domain/homology Component
enucleate erythrocyte development / positive regulation of type II interferon-mediated signaling pathway / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche / G0 to G1 transition / thyroid hormone receptor signaling pathway / core mediator complex ... enucleate erythrocyte development / positive regulation of type II interferon-mediated signaling pathway / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche / G0 to G1 transition / thyroid hormone receptor signaling pathway / core mediator complex / regulation of vitamin D receptor signaling pathway / ventricular trabecula myocardium morphogenesis / thyroid hormone generation / nuclear retinoic acid receptor binding / mediator complex / positive regulation of keratinocyte differentiation / Generic Transcription Pathway / embryonic heart tube development / cellular response to thyroid hormone stimulus / positive regulation of hepatocyte proliferation / prostaglandin receptor activity / regulation of cholesterol transporter activity / negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / embryonic hindlimb morphogenesis / nuclear vitamin D receptor binding / peroxisome proliferator activated receptor binding / MECP2 regulates transcription factors / negative regulation of extracellular matrix assembly / negative regulation of vascular endothelial cell proliferation / negative regulation of cellular response to transforming growth factor beta stimulus / negative regulation of cardiac muscle hypertrophy in response to stress / lens development in camera-type eye / positive regulation of intracellular estrogen receptor signaling pathway / arachidonic acid binding / positive regulation of low-density lipoprotein receptor activity / embryonic hemopoiesis / nuclear thyroid hormone receptor binding / positive regulation of adiponectin secretion / lipoprotein transport / negative regulation of sequestering of triglyceride / DNA binding domain binding / megakaryocyte development / macrophage derived foam cell differentiation / positive regulation of vascular associated smooth muscle cell apoptotic process / STAT family protein binding / histone acetyltransferase binding / cellular response to steroid hormone stimulus / cellular response to hepatocyte growth factor stimulus / positive regulation of fatty acid metabolic process / response to lipid / RSV-host interactions / negative regulation of SMAD protein signal transduction / LBD domain binding / epithelial cell proliferation involved in mammary gland duct elongation / negative regulation of type II interferon-mediated signaling pathway / fat cell differentiation / negative regulation of cholesterol storage / E-box binding / alpha-actinin binding / lipid homeostasis / negative regulation of vascular associated smooth muscle cell proliferation / mammary gland branching involved in pregnancy / R-SMAD binding / monocyte differentiation / negative regulation of macrophage derived foam cell differentiation / negative regulation of blood vessel endothelial cell migration / negative regulation of lipid storage / cellular response to low-density lipoprotein particle stimulus / general transcription initiation factor binding / negative regulation of BMP signaling pathway / white fat cell differentiation / negative regulation of neuron differentiation / negative regulation of mitochondrial fission / positive regulation of cholesterol efflux / hematopoietic stem cell differentiation / embryonic placenta development / negative regulation of keratinocyte proliferation / retinoic acid receptor signaling pathway / positive regulation of fat cell differentiation / positive regulation of transcription initiation by RNA polymerase II / negative regulation of osteoblast differentiation / cell fate commitment / positive regulation of DNA binding / animal organ regeneration / erythrocyte development / BMP signaling pathway / long-chain fatty acid transport / nuclear retinoid X receptor binding / nuclear receptor-mediated steroid hormone signaling pathway / ubiquitin ligase complex / RNA polymerase II preinitiation complex assembly / regulation of cellular response to insulin stimulus / keratinocyte differentiation / cell maturation / negative regulation of signaling receptor activity / cellular response to epidermal growth factor stimulus / epithelial cell differentiation / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway Similarity search - Function Mediator complex, subunit Med1 / Mediator of RNA polymerase II transcription subunit 1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. ... Mediator complex, subunit Med1 / Mediator of RNA polymerase II transcription subunit 1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Mou, T.C. / Chrisman, I.M. / Hughes, T.S. / Sprang, S.R. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P20GM103546 United States National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) R00DK103116 United States
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2022Title : A structural mechanism of nuclear receptor biased agonism.Authors : Nemetchek, M.D. / Chrisman, I.M. / Rayl, M.L. / Voss, A.H. / Hughes, T.S. History Deposition Apr 27, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 1, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 25, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Mar 1, 2023 Group : Database references / Category : citation / citation_author / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession Revision 1.3 Oct 25, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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