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Structure paper

TitleA structural mechanism of nuclear receptor biased agonism.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 119, Page e2215333119-e2215333119, Year 2022
Publish dateApr 27, 2018 (structure data deposition date)
AuthorsNemetchek, M.D. / Chrisman, I.M. / Rayl, M.L. / Voss, A.H. / Hughes, T.S.
External linksProc. Natl. Acad. Sci. USA / PubMed:36469765
MethodsX-ray diffraction
Resolution1.9 - 2.5 Å
Structure data

PDB-6d94:
Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7rle:
Crystal structure of PPAR gamma in complex with CREB-binding protein and agonist GW1929
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-EDK:
(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordsdna binding protein/AGONIST / Nuclear receptor / Transcription factor / Super agonist / Ligand binding domain / Coactivator / MED1 / DNA BINDING PROTEIN / dna binding protein-AGONIST complex

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