登録情報 | データベース: PDB / ID: 6cvo |
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タイトル | Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex |
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要素 | - Aprataxin
- DNA (5'-D(*AP*AP*CP*AP*GP*C)-3')
- DNA/RNA (5'-R(P*G)-D(P*TP*TP*CP*TP*AP*TP*AP*TP*AP*TP*AP*GP*AP*AP*CP*GP*CP*TP*GP*TP*T)-3')
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キーワード | HYDROLASE/DNA/RNA / protein-DNA complex / DNA repair / 5'-DNA end processing / Histidine Triad domain / HIT domain / Zinc-finger / 5'-DNA end recognition / HYDROLASE-DNA-RNA complex |
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機能・相同性 | 機能・相同性情報
adenosine-5'-diphospho-5'-[DNA] diphosphatase / DNA-3'-diphospho-5'-guanosine diphosphatase / DNA-3'-diphospho-5'-guanosine diphosphatase / DNA 5'-adenosine monophosphate hydrolase activity / polynucleotide 3'-phosphatase activity / single-strand break-containing DNA binding / phosphoglycolate phosphatase activity / single strand break repair / mismatched DNA binding / DNA ligation ...adenosine-5'-diphospho-5'-[DNA] diphosphatase / DNA-3'-diphospho-5'-guanosine diphosphatase / DNA-3'-diphospho-5'-guanosine diphosphatase / DNA 5'-adenosine monophosphate hydrolase activity / polynucleotide 3'-phosphatase activity / single-strand break-containing DNA binding / phosphoglycolate phosphatase activity / single strand break repair / mismatched DNA binding / DNA ligation / phosphoprotein binding / regulation of protein stability / double-stranded RNA binding / single-stranded DNA binding / double-stranded DNA binding / damaged DNA binding / chromatin binding / chromatin / nucleolus / nucleoplasm / nucleus / metal ion binding / cytoplasm類似検索 - 分子機能 : / Aprataxin, C2HE/C2H2/C2HC zinc finger / C2HE / C2H2 / C2HC zinc-binding finger / Scavenger mRNA decapping enzyme C-term binding / PNK, FHA domain / FHA domain / Histidine triad, conserved site / HIT domain signature. / HIT domain profile. / HIT-like domain ...: / Aprataxin, C2HE/C2H2/C2HC zinc finger / C2HE / C2H2 / C2HC zinc-binding finger / Scavenger mRNA decapping enzyme C-term binding / PNK, FHA domain / FHA domain / Histidine triad, conserved site / HIT domain signature. / HIT domain profile. / HIT-like domain / HIT-like / HIT family, subunit A / HIT-like superfamily / SMAD/FHA domain superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE MONOPHOSPHATE / BETA-MERCAPTOETHANOL / DNA / DNA/RNA hybrid / DNA/RNA hybrid (> 10) / Aprataxin類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Schellenberg, M.J. / Tumbale, P.P. / Williams, R.S. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) | 1Z01ES102765 | 米国 |
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引用 | ジャーナル: EMBO J. / 年: 2018 タイトル: Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. 著者: Tumbale, P. / Schellenberg, M.J. / Mueller, G.A. / Fairweather, E. / Watson, M. / Little, J.N. / Krahn, J. / Waddell, I. / London, R.E. / Williams, R.S. |
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履歴 | 登録 | 2018年3月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年8月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年2月20日 | Group: Author supporting evidence / Data collection / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.2 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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