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Structure paper

TitleMechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
Journal, issue, pagesEMBO J., Vol. 37, Year 2018
Publish dateMar 28, 2018 (structure data deposition date)
AuthorsTumbale, P. / Schellenberg, M.J. / Mueller, G.A. / Fairweather, E. / Watson, M. / Little, J.N. / Krahn, J. / Waddell, I. / London, R.E. / Williams, R.S.
External linksEMBO J. / PubMed:29934293
MethodsX-ray diffraction
Resolution1.65 - 2.941 Å
Structure data

PDB-6cvo:
Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6cvp:
Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex
Method: X-RAY DIFFRACTION / Resolution: 1.999 Å

PDB-6cvq:
Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6cvr:
Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-6cvs:
Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-6cvt:
Human Aprataxin (Aptx) V263G bound to RNA-DNA, AMP and Zn product complex
Method: X-RAY DIFFRACTION / Resolution: 2.941 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-ZN:
Unknown entry

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsHYDROLASE/DNA/RNA / protein-DNA complex / DNA repair / 5'-DNA end processing / Histidine Triad domain / HIT domain / Zinc-finger / 5'-DNA end recognition / HYDROLASE-DNA-RNA complex / HYDROLASE / hydrolase/dna / hydrolase-dna complex

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