Entry Database : PDB / ID : 6aqb Structure visualization Downloads & linksTitle Structure of the SH3 domain of MLK3 bound to peptide generated from phage display ComponentsChimera protein of MLK3-SH3 and MIP (E.C.2.7.11.25) Details Keywords TRANSFERASE / MLK3 / SH3 / phage display / signalling proteinFunction / homology Function and homology informationFunction Domain/homology Component
mitogen-activated protein kinase kinase kinase / cell cycle G1/S phase transition / JUN kinase kinase kinase activity / mitogen-activated protein kinase kinase kinase binding / mitogen-activated protein kinase kinase binding / RHOV GTPase cycle / microtubule-based process / CDC42 GTPase cycle / RHOG GTPase cycle / MAP kinase kinase kinase activity ... mitogen-activated protein kinase kinase kinase / cell cycle G1/S phase transition / JUN kinase kinase kinase activity / mitogen-activated protein kinase kinase kinase binding / mitogen-activated protein kinase kinase binding / RHOV GTPase cycle / microtubule-based process / CDC42 GTPase cycle / RHOG GTPase cycle / MAP kinase kinase kinase activity / positive regulation of JUN kinase activity / JNK cascade / positive regulation of JNK cascade / RAF activation / small GTPase binding / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / MAPK cascade / positive regulation of neuron apoptotic process / microtubule / protein autophosphorylation / protein kinase activity / positive regulation of apoptotic process / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / protein homodimerization activity / ATP binding / identical protein binding / membrane / cytosol Similarity search - Function MLK1-3, SH3 domain / Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4 / Variant SH3 domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site ... MLK1-3, SH3 domain / Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4 / Variant SH3 domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.5 Å DetailsAuthors Kall, S.K. / Lavie, A. CitationJournal : J. Biol. Chem. / Year : 2018Title : Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.Authors : Kokoszka, M.E. / Kall, S.L. / Khosla, S. / McGinnis, J.E. / Lavie, A. / Kay, B.K. History Deposition Aug 19, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 4, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Dec 26, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Mar 13, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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