Entry Database : PDB / ID : 6a93 Structure visualization Downloads & linksTitle Crystal structure of 5-HT2AR in complex with risperidone Components5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 Details Keywords MEMBRANE PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of heat generation / protein localization to cytoskeleton / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / Gq/11-coupled serotonin receptor activity / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / G protein-coupled serotonin receptor signaling pathway / G protein-coupled serotonin receptor complex / neurofilament / positive regulation of cytokine production involved in immune response ... positive regulation of heat generation / protein localization to cytoskeleton / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / Gq/11-coupled serotonin receptor activity / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / G protein-coupled serotonin receptor signaling pathway / G protein-coupled serotonin receptor complex / neurofilament / positive regulation of cytokine production involved in immune response / artery smooth muscle contraction / Serotonin receptors / cell body fiber / serotonin receptor signaling pathway / sensitization / urinary bladder smooth muscle contraction / protein tyrosine kinase activator activity / serotonin binding / negative regulation of synaptic transmission, glutamatergic / G protein-coupled serotonin receptor activity / positive regulation of platelet aggregation / : / neurotransmitter receptor activity / temperature homeostasis / positive regulation of DNA biosynthetic process / positive regulation of fat cell differentiation / regulation of dopamine secretion / positive regulation of execution phase of apoptosis / negative regulation of potassium ion transport / detection of temperature stimulus involved in sensory perception of pain / behavioral response to cocaine / positive regulation of vasoconstriction / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / detection of mechanical stimulus involved in sensory perception of pain / release of sequestered calcium ion into cytosol / presynaptic modulation of chemical synaptic transmission / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of glycolytic process / dendritic shaft / caveola / glycolytic process / electron transport chain / memory / intracellular calcium ion homeostasis / positive regulation of inflammatory response / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of neuron apoptotic process / virus receptor activity / presynaptic membrane / positive regulation of cytosolic calcium ion concentration / cytoplasmic vesicle / G alpha (q) signalling events / chemical synaptic transmission / postsynaptic membrane / positive regulation of ERK1 and ERK2 cascade / periplasmic space / electron transfer activity / response to xenobiotic stimulus / iron ion binding / axon / neuronal cell body / positive regulation of cell population proliferation / glutamatergic synapse / dendrite / heme binding / protein-containing complex binding / identical protein binding / plasma membrane Similarity search - Function 5-Hydroxytryptamine 2A receptor / 5-hydroxytryptamine receptor family / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) Similarity search - Domain/homologyBiological species Homo sapiens (human)Escherichia coli (E. coli)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Kimura, T.K. / Asada, H. / Inoue, A. / Kadji, F.M.N. / Im, D. / Mori, C. / Arakawa, T. / Hirata, K. / Nomura, Y. / Nomura, N. ...Kimura, T.K. / Asada, H. / Inoue, A. / Kadji, F.M.N. / Im, D. / Mori, C. / Arakawa, T. / Hirata, K. / Nomura, Y. / Nomura, N. / Aoki, J. / Iwata, S. / Shimamura, T. Funding support Japan, 1items Details Hide detailsOrganization Grant number Country Japan
CitationJournal : Nat.Struct.Mol.Biol. / Year : 2019Title : Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.Authors : Kimura, K.T. / Asada, H. / Inoue, A. / Kadji, F.M.N. / Im, D. / Mori, C. / Arakawa, T. / Hirata, K. / Nomura, Y. / Nomura, N. / Aoki, J. / Iwata, S. / Shimamura, T. History Deposition Jul 11, 2018 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 13, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Nov 20, 2019 Group : Database references / Category : citation / citation_authorItem : _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed ... _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id
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