- PDB-4iar: Crystal structure of the chimeric protein of 5-HT1B-BRIL in compl... -
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Basic information
Entry
Database: PDB / ID: 4iar
Title
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)
Components
Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562
Keywords
SIGNALING PROTEIN / ELECTRON TRANSPORT / ergotamine / Novel protein engineering / GPCR Network / Membrane protein / PSI-Biology / Structural Genomics / GPCR / GPCR Dock
Function / homology
Function and homology information
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / adenylate cyclase-inhibiting serotonin receptor signaling pathway / negative regulation of gamma-aminobutyric acid secretion / G protein-coupled serotonin receptor complex / serotonergic synapse / regulation of behavior / Serotonin receptors / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / negative regulation of serotonin secretion ...voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / adenylate cyclase-inhibiting serotonin receptor signaling pathway / negative regulation of gamma-aminobutyric acid secretion / G protein-coupled serotonin receptor complex / serotonergic synapse / regulation of behavior / Serotonin receptors / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / negative regulation of serotonin secretion / drinking behavior / cellular response to temperature stimulus / serotonin binding / bone remodeling / negative regulation of synaptic transmission, glutamatergic / G protein-coupled serotonin receptor activity / vasoconstriction / protein kinase C-activating G protein-coupled receptor signaling pathway / neurotransmitter receptor activity / G protein-coupled receptor internalization / regulation of synaptic vesicle exocytosis / regulation of dopamine secretion / heterocyclic compound binding / cellular response to alkaloid / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / calyx of Held / positive regulation of vascular associated smooth muscle cell proliferation / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / presynaptic modulation of chemical synaptic transmission / response to cocaine / cellular response to xenobiotic stimulus / presynaptic membrane / G alpha (i) signalling events / chemical synaptic transmission / response to ethanol / electron transfer activity / periplasmic space / iron ion binding / dendrite / heme binding / endoplasmic reticulum / plasma membrane Similarity search - Function
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