登録情報 | データベース: PDB / ID: 4iar |
---|
タイトル | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target) |
---|
要素 | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562 |
---|
キーワード | SIGNALING PROTEIN / ELECTRON TRANSPORT (電子伝達系) / ergotamine (エルゴタミン) / Novel protein engineering / GPCR Network / Membrane protein (膜タンパク質) / PSI-Biology / Structural Genomics (構造ゲノミクス) / GPCR (Gタンパク質共役受容体) / GPCR Dock |
---|
機能・相同性 | 機能・相同性情報
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / adenylate cyclase-inhibiting serotonin receptor signaling pathway / negative regulation of gamma-aminobutyric acid secretion / G protein-coupled serotonin receptor complex / serotonergic synapse / regulation of behavior / セロトニン受容体 / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / negative regulation of serotonin secretion ...voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / adenylate cyclase-inhibiting serotonin receptor signaling pathway / negative regulation of gamma-aminobutyric acid secretion / G protein-coupled serotonin receptor complex / serotonergic synapse / regulation of behavior / セロトニン受容体 / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / negative regulation of serotonin secretion / 急性アルコール中毒 / cellular response to temperature stimulus / serotonin binding / bone remodeling / negative regulation of synaptic transmission, glutamatergic / G protein-coupled serotonin receptor activity / 血管収縮 / protein kinase C-activating G protein-coupled receptor signaling pathway / neurotransmitter receptor activity / G protein-coupled receptor internalization / regulation of synaptic vesicle exocytosis / regulation of dopamine secretion / heterocyclic compound binding / cellular response to alkaloid / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / ヘルト萼状シナプス / positive regulation of vascular associated smooth muscle cell proliferation / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / presynaptic modulation of chemical synaptic transmission / response to cocaine / cellular response to xenobiotic stimulus / presynaptic membrane / G alpha (i) signalling events / chemical synaptic transmission / response to ethanol / electron transfer activity / ペリプラズム / iron ion binding / 樹状突起 / heme binding / 小胞体 / 細胞膜類似検索 - 分子機能 5-Hydroxytryptamine 1B receptor / 5-hydroxytryptamine receptor family / Cytochrome c/b562 / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / Four Helix Bundle (Hemerythrin (Met), subunit A) ...5-Hydroxytryptamine 1B receptor / 5-hydroxytryptamine receptor family / Cytochrome c/b562 / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / Four Helix Bundle (Hemerythrin (Met), subunit A) / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 エルゴタミン / (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Soluble cytochrome b562 / 5-hydroxytryptamine receptor 1B類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) Escherichia coli (大腸菌) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
---|
データ登録者 | Wang, C. / Jiang, Y. / Ma, J. / Wu, H. / Wacker, D. / Katritch, V. / Han, G.W. / Liu, W. / Huang, X. / Vardy, E. ...Wang, C. / Jiang, Y. / Ma, J. / Wu, H. / Wacker, D. / Katritch, V. / Han, G.W. / Liu, W. / Huang, X. / Vardy, E. / McCorvy, J.D. / Gao, X. / Zhou, E.X. / Melcher, K. / Zhang, C. / Bai, F. / Yang, H. / Yang, L. / Jiang, H. / Roth, B.L. / Cherezov, V. / Stevens, R.C. / Xu, H.E. / GPCR Network (GPCR) |
---|
引用 | ジャーナル: Science / 年: 2013 タイトル: Structural basis for molecular recognition at serotonin receptors. 著者: Wang, C. / Jiang, Y. / Ma, J. / Wu, H. / Wacker, D. / Katritch, V. / Han, G.W. / Liu, W. / Huang, X.P. / Vardy, E. / McCorvy, J.D. / Gao, X. / Zhou, X.E. / Melcher, K. / Zhang, C. / Bai, F. / ...著者: Wang, C. / Jiang, Y. / Ma, J. / Wu, H. / Wacker, D. / Katritch, V. / Han, G.W. / Liu, W. / Huang, X.P. / Vardy, E. / McCorvy, J.D. / Gao, X. / Zhou, X.E. / Melcher, K. / Zhang, C. / Bai, F. / Yang, H. / Yang, L. / Jiang, H. / Roth, B.L. / Cherezov, V. / Stevens, R.C. / Xu, H.E. |
---|
履歴 | 登録 | 2012年12月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2013年3月13日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年4月10日 | Group: Database references |
---|
改定 1.2 | 2013年5月15日 | Group: Database references |
---|
改定 1.3 | 2013年12月18日 | Group: Derived calculations |
---|
改定 1.4 | 2017年6月7日 | Group: Database references / Structure summary |
---|
改定 1.5 | 2017年11月15日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
---|
改定 1.6 | 2022年2月2日 | Group: Database references / Derived calculations カテゴリ: database_2 / struct_ref_seq ...database_2 / struct_ref_seq / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_ref_seq.seq_align_end / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
改定 1.7 | 2023年9月20日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|