登録情報 | データベース: PDB / ID: 5uwo |
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タイトル | Crystal Structure of Engineered FMRP-1b NES Peptide in complex with CRM1-Ran-RanBP1 |
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要素 | - Engineered FMRP-1b peptide
- Exportin-1
- GTP-binding nuclear protein Ran
- Ran-specific GTPase-activating protein 1
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キーワード | PROTEIN TRANSPORT / HEAT repeat / NES / nuclear export / Karyopherin |
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機能・相同性 | 機能・相同性情報
positive regulation of intracellular transport of viral material / regulation of translation at presynapse, modulating synaptic transmission / modulation by host of viral RNA genome replication / regulation of neuronal action potential / growth cone filopodium / poly(G) binding / positive regulation of miRNA-mediated gene silencing / negative regulation of miRNA-mediated gene silencing / negative regulation of long-term synaptic depression / neuronal ribonucleoprotein granule ...positive regulation of intracellular transport of viral material / regulation of translation at presynapse, modulating synaptic transmission / modulation by host of viral RNA genome replication / regulation of neuronal action potential / growth cone filopodium / poly(G) binding / positive regulation of miRNA-mediated gene silencing / negative regulation of miRNA-mediated gene silencing / negative regulation of long-term synaptic depression / neuronal ribonucleoprotein granule / animal organ development / negative regulation of voltage-gated calcium channel activity / dendritic filopodium / positive regulation of mitotic centrosome separation / RNA strand annealing activity / chromocenter / regulation of dendritic spine development / positive regulation of long-term neuronal synaptic plasticity / filopodium tip / regulation of neurotransmitter secretion / RNA nuclear export complex / pre-miRNA export from nucleus / nuclear export signal receptor activity / snRNA import into nucleus / Transport of Mature mRNA derived from an Intron-Containing Transcript / cellular response to mineralocorticoid stimulus / Regulation of HSF1-mediated heat shock response / regulation of filopodium assembly / manchette / negative regulation of synaptic vesicle exocytosis / non-membrane-bounded organelle assembly / Regulation of cholesterol biosynthesis by SREBP (SREBF) / regulatory ncRNA-mediated gene silencing / poly(A) binding / positive regulation of proteasomal protein catabolic process / SUMOylation of SUMOylation proteins / importin-alpha family protein binding / N6-methyladenosine-containing RNA reader activity / siRNA binding / spindle pole body / protein localization to kinetochore / SUMOylation of RNA binding proteins / protein localization to nucleolus / U4 snRNA binding / Rev-mediated nuclear export of HIV RNA / poly(U) RNA binding / glutamate receptor signaling pathway / sequence-specific mRNA binding / nuclear export / Nuclear import of Rev protein / GTP metabolic process / NEP/NS2 Interacts with the Cellular Export Machinery / tRNA processing in the nucleus / RNA export from nucleus / SUMOylation of chromatin organization proteins / Postmitotic nuclear pore complex (NPC) reformation / MicroRNA (miRNA) biogenesis / miRNA binding / positive regulation of filopodium assembly / nuclear import signal receptor activity / intracellular non-membrane-bounded organelle / DNA metabolic process / dynein intermediate chain binding / NLS-bearing protein import into nucleus / dynein complex binding / positive regulation of dendritic spine development / dendritic spine neck / MAPK6/MAPK4 signaling / regulation of alternative mRNA splicing, via spliceosome / mitotic sister chromatid segregation / glial cell projection / positive regulation of receptor internalization / chromosome, centromeric region / spermatid development / ribosomal large subunit export from nucleus / sperm flagellum / mRNA transport / U5 snRNA binding / ribosomal small subunit export from nucleus / negative regulation of cytoplasmic translation / translation regulator activity / U2 snRNA binding / U6 snRNA binding / mRNA export from nucleus / ribosomal subunit export from nucleus / nuclear pore / signaling adaptor activity / Cajal body / stress granule assembly / axon terminus / U1 snRNA binding / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / regulation of mRNA stability / methylated histone binding / centriole / protein export from nucleus / viral process / RNA splicing類似検索 - 分子機能 Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / : / : / : / : / Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / Fragile X messenger ribonucleoprotein 1, C-terminal core / Fragile X messenger ribonucleoprotein 1 / Synaptic functional regulator FMRP, KH0 domain / FMR1, tudor domain ...Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / : / : / : / : / Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / Fragile X messenger ribonucleoprotein 1, C-terminal core / Fragile X messenger ribonucleoprotein 1 / Synaptic functional regulator FMRP, KH0 domain / FMR1, tudor domain / Fragile X-related 1 protein core C terminal / FMRP KH0 domain / Fragile X messenger ribonucleoprotein 1, Tudor domain / Agenet-like domain profile. / Agenet-like domain / Agenet domain / Ran-specific GTPase-activating protein 1, Ran-binding domain / Exportin-1, C-terminal / Exportin-1, repeat 3 / Chromosome region maintenance repeat / Exportin-1, repeat 2 / CRM1 C terminal / Chromosome region maintenance or exportin repeat / CRM1 / Exportin repeat 2 / CRM1 / Exportin repeat 3 / CRM1 C terminal / Exportin-1/5 / Exportin-1/Importin-beta-like / Exportin 1-like protein / Ran binding protein RanBP1-like / Ran binding domain / RanBP1 domain / Ran binding domain type 1 profile. / Ran-binding domain / small GTPase Ran family profile. / Ran GTPase / Importin-beta N-terminal domain profile. / Importin-beta N-terminal domain / Importin-beta N-terminal domain / Importin-beta, N-terminal domain / KH domain / K Homology domain, type 1 / Type-1 KH domain profile. / K Homology domain, type 1 superfamily / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / K Homology domain / K homology RNA-binding domain / Armadillo-like helical / Small GTP-binding protein domain / PH-like domain superfamily / Armadillo-type fold / P-loop containing nucleotide triphosphate hydrolases / Roll / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Exportin-1 / Ran-specific GTPase-activating protein 1 / GTP-binding nuclear protein Ran / Fragile X messenger ribonucleoprotein 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Saccharomyces cerevisiae (パン酵母) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.347 Å |
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データ登録者 | Fung, H.Y.J. / Chook, Y.M. |
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資金援助 | 米国, 香港, 7件 組織 | 認可番号 | 国 |
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Howard Hughes Medical Institute (HHMI) | International Student Research Fellowship | 米国 | Croucher Foundation | Predoc Research Scholarship | 香港 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM069909 | 米国 | Welch Foundation | I-1532 | 米国 | Leukemia & Lymphoma Society | Scholar Award | 米国 | University of Texas Southwestern Medical Center | Endowed Scholars Program | 米国 | Cancer Prevention and Research Institute of Texas (CPRIT) | RP120352, RP150053 | 米国 |
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引用 | ジャーナル: Elife / 年: 2017 タイトル: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. 著者: Fung, H.Y. / Fu, S.C. / Chook, Y.M. |
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履歴 | 登録 | 2017年2月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年3月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月13日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.2 | 2017年9月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年4月24日 | Group: Author supporting evidence / Data collection / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2019年11月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id |
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