- PDB-5uwa: Structure of E. coli phospholipid binding protein MlaC -
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基本情報
登録情報
データベース: PDB / ID: 5uwa
タイトル
Structure of E. coli phospholipid binding protein MlaC
要素
Probable phospholipid-binding protein MlaC
キーワード
TRANSPORT PROTEIN / phospholipid-binding protein / bacterial lipid transport
機能・相同性
Tgt2/MlaC superfamily / Toluene tolerance Ttg2/phospholipid-binding protein MlaC / MlaC protein / intermembrane phospholipid transfer / phospholipid transport / outer membrane-bounded periplasmic space / Chem-8ND / Intermembrane phospholipid transport system binding protein MlaC
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
K99GM112982
米国
Damon Runyon Cancer Research Foundation
DRG-2140-12
米国
Howard Hughes Medical Institute (HHMI)
米国
引用
ジャーナル: Cell / 年: 2017 タイトル: Architectures of Lipid Transport Systems for the Bacterial Outer Membrane. 著者: Damian C Ekiert / Gira Bhabha / Georgia L Isom / Garrett Greenan / Sergey Ovchinnikov / Ian R Henderson / Jeffery S Cox / Ronald D Vale / 要旨: How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) ...How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel capable of mediating lipid transport. The E. coli MCE protein, MlaD, forms a ring associated with an ABC transporter complex in the inner membrane. A soluble lipid-binding protein, MlaC, ferries lipids between MlaD and an outer membrane protein complex. In contrast, EM structures of two other E. coli MCE proteins show that YebT forms an elongated tube consisting of seven stacked MCE rings, and PqiB adopts a syringe-like architecture. Both YebT and PqiB create channels of sufficient length to span the periplasmic space. This work reveals diverse architectures of highly conserved protein-based channels implicated in the transport of lipids between the membranes of bacteria and some eukaryotic organelles.