登録情報 | データベース: PDB / ID: 5sxp |
---|
タイトル | STRUCTURAL BASIS FOR THE INTERACTION BETWEEN ITCH PRR AND BETA-PIX |
---|
要素 | - E3 ubiquitin-protein ligase Itchy homolog
- Rho guanine nucleotide exchange factor 7
|
---|
キーワード | SIGNALING PROTEIN/LIGASE / SH3 DOMAIN PEPTIDE LIGAND COMPLEX / LIGASE / SIGNALING PROTEIN-LIGASE complex |
---|
機能・相同性 | 機能・相同性情報
negative regulation of microtubule nucleation / regulation of protein deubiquitination / negative regulation of cytoplasmic pattern recognition receptor signaling pathway / ubiquitin-like protein transferase activity / negative regulation of defense response to virus / nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / protein K29-linked ubiquitination / T cell anergy / CXCR chemokine receptor binding / regulation of necroptotic process ...negative regulation of microtubule nucleation / regulation of protein deubiquitination / negative regulation of cytoplasmic pattern recognition receptor signaling pathway / ubiquitin-like protein transferase activity / negative regulation of defense response to virus / nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / protein K29-linked ubiquitination / T cell anergy / CXCR chemokine receptor binding / regulation of necroptotic process / positive regulation of T cell anergy / protein branched polyubiquitination / CD4-positive, alpha-beta T cell proliferation / negative regulation of CD4-positive, alpha-beta T cell proliferation / focal adhesion assembly / HECT-type E3 ubiquitin transferase / arrestin family protein binding / gamma-tubulin binding / positive regulation of lamellipodium morphogenesis / Ephrin signaling / regulation of hematopoietic stem cell differentiation / negative regulation of JNK cascade / positive regulation of fibroblast migration / lamellipodium assembly / ubiquitin-ubiquitin ligase activity / negative regulation of type I interferon production / positive regulation of receptor catabolic process / RHOV GTPase cycle / Activation of RAC1 downstream of NMDARs / NRAGE signals death through JNK / mitotic spindle pole / ligase activity / RHOJ GTPase cycle / Golgi organization / RHOQ GTPase cycle / ubiquitin-like protein ligase binding / RHOU GTPase cycle / CDC42 GTPase cycle / protein K63-linked ubiquitination / RHOA GTPase cycle / protein monoubiquitination / Rho protein signal transduction / ephrin receptor signaling pathway / ribonucleoprotein complex binding / protein K48-linked ubiquitination / protein autoubiquitination / ruffle / positive regulation of GTPase activity / negative regulation of canonical NF-kappaB signal transduction / RAC1 GTPase cycle / positive regulation of substrate adhesion-dependent cell spreading / Downregulation of ERBB4 signaling / Activated NOTCH1 Transmits Signal to the Nucleus / guanyl-nucleotide exchange factor activity / Negative regulators of DDX58/IFIH1 signaling / regulation of cell growth / EGFR downregulation / Degradation of GLI1 by the proteasome / Hedgehog 'on' state / NOD1/2 Signaling Pathway / receptor internalization / Regulation of necroptotic cell death / positive regulation of protein catabolic process / ubiquitin-protein transferase activity / SARS-CoV-1 activates/modulates innate immune responses / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / G alpha (12/13) signalling events / nervous system development / lamellipodium / RUNX1 regulates transcription of genes involved in differentiation of HSCs / ubiquitin-dependent protein catabolic process / cytoplasmic vesicle / cell cortex / early endosome membrane / defense response to virus / proteasome-mediated ubiquitin-dependent protein catabolic process / postsynapse / neuron projection / protein ubiquitination / positive regulation of apoptotic process / inflammatory response / symbiont entry into host cell / innate immune response / focal adhesion / neuronal cell body / intracellular membrane-bounded organelle / apoptotic process / centrosome / negative regulation of apoptotic process / protein kinase binding / signal transduction / protein-containing complex / mitochondrion / extracellular exosome / nucleoplasm / membrane / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Unstructured region one on RhoGEF 6 and 7 / Rho guanine nucleotide exchange factor 7, SH3 domain / RhoGEF 6/7, PH domain / Unstructured region two on RhoGEF 6 and 7 / E3 ubiquitin-protein ligase, SMURF1 type / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / : / HECT domain / HECT, E3 ligase catalytic domain ...Unstructured region one on RhoGEF 6 and 7 / Rho guanine nucleotide exchange factor 7, SH3 domain / RhoGEF 6/7, PH domain / Unstructured region two on RhoGEF 6 and 7 / E3 ubiquitin-protein ligase, SMURF1 type / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / : / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / Variant SH3 domain / Calponin homology domain / Calponin homology (CH) domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Protein kinase C conserved region 2 (CalB) / C2 domain / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / SH3 Domains / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Src homology 3 domains / SH3 type barrels. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Rho guanine nucleotide exchange factor 7 / E3 ubiquitin-protein ligase Itchy homolog類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.65 Å |
---|
データ登録者 | Cappadocia, L. / Desrochers, G. / Lussier-Price, M. / Angers, A. / Omichinski, J.G. |
---|
資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
---|
Natural Sciences and Engineering Research Council (NSERC, Canada) | 312158 | カナダ |
|
---|
引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. 著者: Desrochers, G. / Cappadocia, L. / Lussier-Price, M. / Ton, A.T. / Ayoubi, R. / Serohijos, A. / Omichinski, J.G. / Angers, A. |
---|
履歴 | 登録 | 2016年8月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2017年3月1日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年3月15日 | Group: Data collection / Database references |
---|
改定 1.2 | 2017年4月26日 | Group: Database references |
---|
改定 1.3 | 2017年9月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.4 | 2020年1月8日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.5 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|