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Yorodumi- PDB-5mbr: Quadruplex with flipped tetrad formed by a human telomeric sequence -
+Open data
-Basic information
Entry | Database: PDB / ID: 5mbr | ||||||
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Title | Quadruplex with flipped tetrad formed by a human telomeric sequence | ||||||
Components | G-quadruplex formed by a human telomeric sequence modified with 2'-fluoro-2'-deoxyriboguanosine | ||||||
Keywords | DNA / G-quadruplex / human telomere | ||||||
Function / homology | DNA / DNA (> 10) Function and homology information | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / DGSA-distance geometry simulated annealing | ||||||
Authors | Dickerhoff, J. / Haase, L. / Langel, W. / Weisz, K. | ||||||
Citation | Journal: ACS Chem. Biol. / Year: 2017 Title: Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes. Authors: Dickerhoff, J. / Haase, L. / Langel, W. / Weisz, K. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5mbr.cif.gz | 155.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5mbr.ent.gz | 126.5 KB | Display | PDB format |
PDBx/mmJSON format | 5mbr.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5mbr_validation.pdf.gz | 327.9 KB | Display | wwPDB validaton report |
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Full document | 5mbr_full_validation.pdf.gz | 383.1 KB | Display | |
Data in XML | 5mbr_validation.xml.gz | 9.2 KB | Display | |
Data in CIF | 5mbr_validation.cif.gz | 13.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/mb/5mbr ftp://data.pdbj.org/pub/pdb/validation_reports/mb/5mbr | HTTPS FTP |
-Related structure data
Related structure data | 5mcrC C: citing same article (ref.) |
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Similar structure data | |
Other databases |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: DNA chain | Mass: 7645.855 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: telomere / Source: (synth.) Homo sapiens (human) |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample |
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Sample conditions | Ionic strength: 10 mM / Label: conditions_1 / pH: 7.0 / Pressure: 1 atm / Temperature: 298 K |
-NMR measurement
NMR spectrometer | Type: Bruker AVANCE / Manufacturer: Bruker / Model: AVANCE / Field strength: 600 MHz |
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-Processing
NMR software |
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Refinement | Method: DGSA-distance geometry simulated annealing / Software ordinal: 1 | ||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: all calculated structures submitted Conformers calculated total number: 10 / Conformers submitted total number: 10 |