Entry | Database: PDB / ID: 5hzp |
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Title | Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein. |
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Components | - C4b-binding protein alpha chain
- M protein, serotype 49
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Keywords | IMMUNE SYSTEM / M protein / Compliment / Streptococcus pyogenes / hypervariable antigen |
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Function / homology | Function and homology information
regulation of opsonization / response to symbiotic bacterium / negative regulation of complement activation, classical pathway / T cell mediated immunity / cell wall / : / phagocytosis / complement activation, classical pathway / Regulation of Complement cascade / positive regulation of protein catabolic process ...regulation of opsonization / response to symbiotic bacterium / negative regulation of complement activation, classical pathway / T cell mediated immunity / cell wall / : / phagocytosis / complement activation, classical pathway / Regulation of Complement cascade / positive regulation of protein catabolic process / blood microparticle / innate immune response / RNA binding / extracellular space / extracellular region / plasma membraneSimilarity search - Function C4b-binding protein alpha, oligomerization domain / Oligomerization domain of C4b-binding protein alpha / M protein repeat / M protein repeat / : / M protein-type anchor domain / Complement Module, domain 1 / Complement Module; domain 1 / YSIRK type signal peptide / Sushi repeat (SCR repeat) ...C4b-binding protein alpha, oligomerization domain / Oligomerization domain of C4b-binding protein alpha / M protein repeat / M protein repeat / : / M protein-type anchor domain / Complement Module, domain 1 / Complement Module; domain 1 / YSIRK type signal peptide / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / YSIRK Gram-positive signal peptide / LPXTG cell wall anchor motif / Gram-positive cocci surface proteins LPxTG motif profile. / LPXTG cell wall anchor domain / Ribbon / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Streptococcus pyogenes serotype M49 (bacteria)
Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.74 Å |
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Authors | Buffalo, C.Z. / Bahn-Suh, A.J. / Ghosh, P. |
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Funding support | United States, 4items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | t32 GM007240 | United States | American Heart Association | 14PRE18320032 | United States | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI096837 | United States | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI077780 | United States |
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Citation | Journal: Nat Microbiol / Year: 2016 Title: Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Authors: Buffalo, C.Z. / Bahn-Suh, A.J. / Hirakis, S.P. / Biswas, T. / Amaro, R.E. / Nizet, V. / Ghosh, P. |
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History | Deposition | Feb 2, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 20, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 26, 2016 | Group: Database references |
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Revision 1.2 | Sep 13, 2017 | Group: Author supporting evidence / Derived calculations / Category: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.3 | Oct 4, 2017 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.4 | Dec 11, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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