Entry Database : PDB / ID : 5h1k Structure visualization Downloads & linksTitle Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment ComponentsGem-associated protein 5 U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3') DetailsKeywords SPLICING/RNA / WD repeat / Gemin5 / SMN / RNA binding / U4 snRNA / SPLICING-RNA complexFunction / homology Function and homology informationFunction Domain/homology Component
SMN-Gemin2 complex / Gemini of coiled bodies / SMN complex / U4atac snRNA binding / snRNA binding / RNA 7-methylguanosine cap binding / SMN-Sm protein complex / U4 snRNA binding / spliceosomal snRNP assembly / U1 snRNA binding ... SMN-Gemin2 complex / Gemini of coiled bodies / SMN complex / U4atac snRNA binding / snRNA binding / RNA 7-methylguanosine cap binding / SMN-Sm protein complex / U4 snRNA binding / spliceosomal snRNP assembly / U1 snRNA binding / mRNA 3'-UTR binding / mRNA splicing, via spliceosome / ribosome binding / regulation of translation / snRNP Assembly / SARS-CoV-2 modulates host translation machinery / protein-containing complex assembly / nuclear body / translation / RNA binding / nucleoplasm / membrane / nucleus / cytoplasm / cytosol Similarity search - Function MIOS, WD40 repeat / Anaphase-promoting complex subunit 4, WD40 domain / Anaphase-promoting complex subunit 4 WD40 domain / Quinoprotein alcohol dehydrogenase-like superfamily / YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. ... MIOS, WD40 repeat / Anaphase-promoting complex subunit 4, WD40 domain / Anaphase-promoting complex subunit 4 WD40 domain / Quinoprotein alcohol dehydrogenase-like superfamily / YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Wang, Y. / Jin, W. / Liu, C.P. / Yang, N. / Jin, M. / Cong, Y. / Wang, M. / Xu, R.M. Funding support China, 6items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31570747 China National Natural Science Foundation of China 31622020 China National Natural Science Foundation of China 31430018 China National Natural Science Foundation of China 31521002 China Beijing Natural Science Foundation 5164038 China Strategic Priority Research Program of Chinese Academy of Sciences XDB08010100 China
CitationJournal : Genes Dev. / Year : 2016Title : Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5Authors : Jin, W. / Wang, Y. / Liu, C.P. / Yang, N. / Jin, M. / Cong, Y. / Wang, M. / Xu, R.M. History Deposition Oct 10, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Nov 23, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Dec 7, 2016 Group : Database referencesRevision 1.2 Oct 18, 2017 Group : Author supporting evidence / Database references / Category : citation / pdbx_audit_supportItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organizationRevision 1.3 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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