Entry | Database: PDB / ID: 5g6v |
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Title | Crystal structure of the PCTAIRE1 kinase in complex with inhibitor |
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Components | CYCLIN-DEPENDENT KINASE 16 |
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Keywords | TRANSFERASE |
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Function / homology | Function and homology information
growth hormone secretion / regulation of insulin secretion involved in cellular response to glucose stimulus / exocytosis / cyclin-dependent protein kinase holoenzyme complex / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / positive regulation of autophagy / cytoplasmic side of plasma membrane / neuron projection development / microtubule cytoskeleton ...growth hormone secretion / regulation of insulin secretion involved in cellular response to glucose stimulus / exocytosis / cyclin-dependent protein kinase holoenzyme complex / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / positive regulation of autophagy / cytoplasmic side of plasma membrane / neuron projection development / microtubule cytoskeleton / synaptic vesicle / spermatogenesis / neuron projection / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function Haspin like kinase domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ...Haspin like kinase domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å |
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Authors | Dixon-Clarke, S.E. / Galan Bartual, S. / Elkins, J. / Savitsky, P. / Kopec, J. / Mackenzie, A. / Tallant, C. / Heroven, C. / Burgess-Brown, N. / von Delft, F. ...Dixon-Clarke, S.E. / Galan Bartual, S. / Elkins, J. / Savitsky, P. / Kopec, J. / Mackenzie, A. / Tallant, C. / Heroven, C. / Burgess-Brown, N. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. |
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Citation | Journal: Biochem.J. / Year: 2017 Title: Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Authors: Dixon-Clarke, S.E. / Shehata, S.N. / Krojer, T. / Sharpe, T.D. / von Delft, F. / Sakamoto, K. / Bullock, A.N. |
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History | Deposition | Aug 16, 2016 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 23, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 2, 2023 | Group: Database references / Derived calculations ...Database references / Derived calculations / Other / Refinement description Category: citation / citation_author ...citation / citation_author / database_2 / pdbx_database_status / struct_ncs_dom_lim / struct_site Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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Revision 1.2 | Jun 19, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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