Entry Database : PDB / ID : 3bbt Structure visualization Downloads & linksTitle crystal structure of the ErbB4 kinase in complex with lapatinib ComponentsReceptor tyrosine-protein kinase erbB-4 Details Keywords TRANSFERASE / inactive kinase conformation / ATP-binding / Glycoprotein / Membrane / Nucleotide-binding / Phosphoprotein / Receptor / Transmembrane / Tyrosine-protein kinaseFunction / homology Function and homology informationFunction Domain/homology Component
establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process ... establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / neuregulin receptor activity / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process / ERBB2 Activates PTK6 Signaling / GABA receptor binding / PI3K events in ERBB4 signaling / mammary gland epithelial cell differentiation / embryonic pattern specification / Signaling by ERBB4 / positive regulation of protein localization to cell surface / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / neural crest cell migration / neurotransmitter receptor localization to postsynaptic specialization membrane / epidermal growth factor receptor binding / cell fate commitment / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / cellular response to epidermal growth factor stimulus / Signaling by ERBB2 / SHC1 events in ERBB4 signaling / GABA-ergic synapse / mammary gland alveolus development / GRB2 events in ERBB2 signaling / transmembrane receptor protein tyrosine kinase activity / neurogenesis / SHC1 events in ERBB2 signaling / basal plasma membrane / Nuclear signaling by ERBB4 / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly / Downregulation of ERBB4 signaling / lactation / regulation of cell migration / Signaling by ERBB2 TMD/JMD mutants / Signaling by ERBB2 KD Mutants / receptor protein-tyrosine kinase / Downregulation of ERBB2 signaling / positive regulation of receptor signaling pathway via JAK-STAT / postsynaptic density membrane / neuromuscular junction / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / cell migration / nervous system development / presynaptic membrane / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / heart development / RAF/MAP kinase cascade / basolateral plasma membrane / protein tyrosine kinase activity / postsynaptic membrane / Estrogen-dependent gene expression / protein autophosphorylation / transcription cis-regulatory region binding / receptor complex / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / mitochondrial matrix / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / positive regulation of cell population proliferation / glutamatergic synapse / positive regulation of DNA-templated transcription / negative regulation of apoptotic process / signal transduction / protein homodimerization activity / mitochondrion / extracellular region / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol Similarity search - Function : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain ... : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / : / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.8 Å DetailsAuthors Qiu, C. CitationJournal : Structure / Year : 2008Title : Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.Authors : Qiu, C. / Tarrant, M.K. / Choi, S.H. / Sathyamurthy, A. / Bose, R. / Banjade, S. / Pal, A. / Bornmann, W.G. / Lemmon, M.A. / Cole, P.A. / Leahy, D.J. History Deposition Nov 11, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 12, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Refinement description / Version format complianceRevision 1.2 Oct 25, 2017 Group : Refinement description / Category : softwareRevision 1.3 Feb 21, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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