- PDB-5abu: Complex of D. melanogaster eIF4E with the 4E-binding protein Mext... -
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基本情報
登録情報
データベース: PDB / ID: 5abu
タイトル
Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog
要素
4E-BINDING PROTEIN MEXTLI
EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
キーワード
TRANSLATION / GENE REGULATION / CAP BINDING PROTEIN / 4E BINDING PROTEIN
機能・相同性
機能・相同性情報
regulation of formation of translation initiation ternary complex / TOR signaling pathway / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / ISG15 antiviral mechanism / Transport of the SLBP independent Mature mRNA / female germ-line stem cell population maintenance / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / mTORC1-mediated signalling / Ribosomal scanning and start codon recognition ...regulation of formation of translation initiation ternary complex / TOR signaling pathway / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / ISG15 antiviral mechanism / Transport of the SLBP independent Mature mRNA / female germ-line stem cell population maintenance / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / mTORC1-mediated signalling / Ribosomal scanning and start codon recognition / L13a-mediated translational silencing of Ceruloplasmin expression / Translation initiation complex formation / muscle cell postsynaptic specialization / trans-synaptic signaling / RNA cap binding complex / neuronal ribonucleoprotein granule / RNA metabolic process / eukaryotic initiation factor 4G binding / eukaryotic initiation factor 4E binding / regulation of translation at postsynapse, modulating synaptic transmission / RNA cap binding / eukaryotic translation initiation factor 4F complex / RNA 7-methylguanosine cap binding / translational initiation / translation initiation factor activity / positive regulation of translation / P-body / neuromuscular junction / postsynapse / nuclear body / translation / RNA binding / cytoplasm / cytosol 類似検索 - 分子機能
Eukaryotic translation initiation factor 4E-binding protein Mextli / RNA Cap, Translation Initiation Factor Eif4e / RNA Cap, Translation Initiation Factor Eif4e / Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like / KH domain / K Homology domain, type 1 ...Eukaryotic translation initiation factor 4E-binding protein Mextli / RNA Cap, Translation Initiation Factor Eif4e / RNA Cap, Translation Initiation Factor Eif4e / Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like / KH domain / K Homology domain, type 1 / Type-1 KH domain profile. / K Homology domain, type 1 superfamily / K Homology domain / K homology RNA-binding domain / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
NUMBERING OF CHAIN A CORRESPONDS TO UNP P48598-2. COMPARED TO UNP P48598, SEQUENCE NUMBERS ARE ...NUMBERING OF CHAIN A CORRESPONDS TO UNP P48598-2. COMPARED TO UNP P48598, SEQUENCE NUMBERS ARE SHIFTED BY -11 RESIDUES. THE FIRST FOUR RESIDUES OF CHAIN A REMAIN FROM THE EXPRESSION TAG. THE FIRST SIX RESIDUES OF CHAIN B REMAIN FROM THE EXPRESSION TAG.
解像度: 2.16→40.882 Å / SU ML: 0.23 / σ(F): 1.38 / 位相誤差: 24.4 / 立体化学のターゲット値: ML 詳細: HYDROGENS WERE REFINED IN THE RIDING POSITIONS. SIDECHAINS OF THE FOLLOWING RESIDUES WERE TRUNCATED AT CB ATOMS. CHAIN A, RESIDUES 67, 68, 150, 190, 237, 243. THE FOLLOWING RESIDUES WERE ...詳細: HYDROGENS WERE REFINED IN THE RIDING POSITIONS. SIDECHAINS OF THE FOLLOWING RESIDUES WERE TRUNCATED AT CB ATOMS. CHAIN A, RESIDUES 67, 68, 150, 190, 237, 243. THE FOLLOWING RESIDUES WERE MODELED AS DOUBLE CONFORMATIONS. CHAIN A, RESIDUES 73, 215. THE FOLLOWING RESIDUES ARE DISORDERED. CHAIN A, RESIDUES 151 TO 153, 238 TO 241. CHAIN B, RESIDUES 636 TO 640. RESTRAINTS FOR THE GTG LIGAND WERE GENERATED WITH GRADE.
Rfactor
反射数
%反射
Rfree
0.2375
739
5.3 %
Rwork
0.1946
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-
obs
0.197
13971
99.37 %
溶媒の処理
減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL