Entry Database : PDB / ID : 4y7r Structure visualization Downloads & linksTitle Crystal structure of WDR5 in complex with MYC MbIIIb peptide ComponentsMYC MbIIIb peptide WD repeat-containing protein 5 DetailsKeywords DNA BINDING PROTEIN / Myc WDR5 CancerFunction / homology Function and homology informationFunction Domain/homology Component
SCF ubiquitin ligase complex binding / positive regulation of metanephric cap mesenchymal cell proliferation / negative regulation of transcription initiation by RNA polymerase II / Myc-Max complex / RNA polymerase II transcription repressor complex / regulation of cell cycle process / regulation of somatic stem cell population maintenance / Binding of TCF/LEF:CTNNB1 to target gene promoters / RUNX3 regulates WNT signaling / TFAP2 (AP-2) family regulates transcription of cell cycle factors ... SCF ubiquitin ligase complex binding / positive regulation of metanephric cap mesenchymal cell proliferation / negative regulation of transcription initiation by RNA polymerase II / Myc-Max complex / RNA polymerase II transcription repressor complex / regulation of cell cycle process / regulation of somatic stem cell population maintenance / Binding of TCF/LEF:CTNNB1 to target gene promoters / RUNX3 regulates WNT signaling / TFAP2 (AP-2) family regulates transcription of cell cycle factors / negative regulation of cell division / negative regulation of monocyte differentiation / transcription regulator activator activity / response to growth factor / Transcription of E2F targets under negative control by DREAM complex / MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / negative regulation of stress-activated MAPK cascade / fibroblast apoptotic process / regulation of telomere maintenance / Regulation of NFE2L2 gene expression / positive regulation of mesenchymal cell proliferation / protein-DNA complex disassembly / negative regulation of gene expression via chromosomal CpG island methylation / regulation of tubulin deacetylation / histone methyltransferase complex / branching involved in ureteric bud morphogenesis / Signaling by ALK / Formation of WDR5-containing histone-modifying complexes / regulation of cell division / E-box binding / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / : / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / regulation of embryonic development / MLL1 complex / histone acetyltransferase complex / chromosome organization / Cyclin E associated events during G1/S transition / core promoter sequence-specific DNA binding / Cyclin A:Cdk2-associated events at S phase entry / negative regulation of fibroblast proliferation / positive regulation of gluconeogenesis / ERK1 and ERK2 cascade / methylated histone binding / transcription initiation-coupled chromatin remodeling / positive regulation of epithelial cell proliferation / skeletal system development / transcription coregulator binding / gluconeogenesis / response to gamma radiation / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / MAPK6/MAPK4 signaling / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NOTCH1 Intracellular Domain Regulates Transcription / mitotic spindle / PKMTs methylate histone lysines / DNA-binding transcription repressor activity, RNA polymerase II-specific / RMTs methylate histone arginines / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / positive regulation of miRNA transcription / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Transcriptional regulation of granulopoiesis / G1/S transition of mitotic cell cycle / cellular response to UV / MAPK cascade / positive regulation of fibroblast proliferation / cellular response to xenobiotic stimulus / Neddylation / HATs acetylate histones / histone binding / cellular response to hypoxia / regulation of gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / DNA-binding transcription factor binding / intracellular iron ion homeostasis / Estrogen-dependent gene expression / protein dimerization activity / regulation of cell cycle / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / response to xenobiotic stimulus / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA damage response / positive regulation of cell population proliferation / regulation of DNA-templated transcription / positive regulation of gene expression / protein-containing complex binding / chromatin / regulation of transcription by RNA polymerase II / nucleolus / negative regulation of apoptotic process Similarity search - Function : / Leucine zipper, Myc / Myc leucine zipper domain / Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Helix-loop-helix DNA-binding domain / YVTN repeat-like/Quinoprotein amine dehydrogenase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain ... : / Leucine zipper, Myc / Myc leucine zipper domain / Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Helix-loop-helix DNA-binding domain / YVTN repeat-like/Quinoprotein amine dehydrogenase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.898 Å DetailsAuthors Sun, Q. / Phan, J. / Olejniczak, E.T. / Thomas, L.R. / Fesik, S.W. / Tansey, W.P. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/Office of the Director 5DP1OD006933 United States
CitationJournal : Mol.Cell / Year : 2015Title : Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.Authors: Thomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. / Alicie, B. / Howard, G.C. / Cawthon, B. / Ess, K.C. / ... Authors : Thomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. / Alicie, B. / Howard, G.C. / Cawthon, B. / Ess, K.C. / Eischen, C.M. / Zhao, Z. / Fesik, S.W. / Tansey, W.P. History Deposition Feb 16, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 15, 2015 Provider : repository / Type : Initial releaseRevision 1.1 May 20, 2015 Group : Database referencesRevision 1.2 Sep 20, 2017 Group : Author supporting evidence / Database references ... Author supporting evidence / Database references / Derived calculations / Source and taxonomy Category : citation / entity_src_gen ... citation / entity_src_gen / pdbx_audit_support / pdbx_entity_src_syn / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_entity_src_syn.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation Revision 1.3 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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