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TitleInteraction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.
Journal, issue, pagesMol. Cell, Vol. 58, Page 440-452, Year 2015
Publish dateFeb 16, 2015 (structure data deposition date)
AuthorsThomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. ...Thomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. / Alicie, B. / Howard, G.C. / Cawthon, B. / Ess, K.C. / Eischen, C.M. / Zhao, Z. / Fesik, S.W. / Tansey, W.P.
External linksMol. Cell / PubMed:25818646
MethodsX-ray diffraction
Resolution1.898 Å
Structure data

PDB-4y7r:
Crystal structure of WDR5 in complex with MYC MbIIIb peptide
Method: X-RAY DIFFRACTION / Resolution: 1.898 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / Myc WDR5 Cancer

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