登録情報 | データベース: PDB / ID: 4y7r |
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タイトル | Crystal structure of WDR5 in complex with MYC MbIIIb peptide |
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要素 | - MYC MbIIIb peptide
- WD repeat-containing protein 5
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キーワード | DNA BINDING PROTEIN (DNA結合タンパク質) / Myc WDR5 Cancer |
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機能・相同性 | 機能・相同性情報
SCF ubiquitin ligase complex binding / positive regulation of metanephric cap mesenchymal cell proliferation / negative regulation of transcription initiation by RNA polymerase II / Myc-Max complex / RNA polymerase II transcription repressor complex / regulation of cell cycle process / regulation of somatic stem cell population maintenance / Binding of TCF/LEF:CTNNB1 to target gene promoters / RUNX3 regulates WNT signaling / TFAP2 (AP-2) family regulates transcription of cell cycle factors ...SCF ubiquitin ligase complex binding / positive regulation of metanephric cap mesenchymal cell proliferation / negative regulation of transcription initiation by RNA polymerase II / Myc-Max complex / RNA polymerase II transcription repressor complex / regulation of cell cycle process / regulation of somatic stem cell population maintenance / Binding of TCF/LEF:CTNNB1 to target gene promoters / RUNX3 regulates WNT signaling / TFAP2 (AP-2) family regulates transcription of cell cycle factors / negative regulation of cell division / negative regulation of monocyte differentiation / DNA methylation-dependent heterochromatin formation / Transcription of E2F targets under negative control by DREAM complex / protein-DNA complex disassembly / transcription regulator activator activity / MLL3/4 complex / response to growth factor / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / : / negative regulation of stress-activated MAPK cascade / regulation of telomere maintenance / Cardiogenesis / fibroblast apoptotic process / Regulation of NFE2L2 gene expression / positive regulation of mesenchymal cell proliferation / histone methyltransferase complex / regulation of tubulin deacetylation / branching involved in ureteric bud morphogenesis / Signaling by ALK / regulation of cell division / Formation of WDR5-containing histone-modifying complexes / E-box binding / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / MLL1 complex / regulation of embryonic development / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / histone acetyltransferase complex / chromosome organization / Cyclin E associated events during G1/S transition / negative regulation of fibroblast proliferation / core promoter sequence-specific DNA binding / Cyclin A:Cdk2-associated events at S phase entry / positive regulation of gluconeogenesis / transcription initiation-coupled chromatin remodeling / positive regulation of telomerase activity / ERK1 and ERK2 cascade / methylated histone binding / skeletal system development / positive regulation of epithelial cell proliferation / 糖新生 / transcription coregulator binding / response to gamma radiation / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / G1/S transition of mitotic cell cycle / MAPK6/MAPK4 signaling / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / 紡錘体 / NOTCH1 Intracellular Domain Regulates Transcription / PKMTs methylate histone lysines / RMTs methylate histone arginines / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / DNA-binding transcription repressor activity, RNA polymerase II-specific / Activation of anterior HOX genes in hindbrain development during early embryogenesis / positive regulation of miRNA transcription / Transcriptional regulation of granulopoiesis / cellular response to UV / positive regulation of fibroblast proliferation / 分裂促進因子活性化タンパク質キナーゼ / cellular response to xenobiotic stimulus / Neddylation / HATs acetylate histones / histone binding / cellular response to hypoxia / 遺伝子発現の調節 / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / DNA-binding transcription factor binding / Estrogen-dependent gene expression / intracellular iron ion homeostasis / protein dimerization activity / regulation of cell cycle / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / クロマチンリモデリング / response to xenobiotic stimulus / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA damage response / positive regulation of cell population proliferation / クロマチン / protein-containing complex binding / positive regulation of gene expression / 核小体 / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II類似検索 - 分子機能 Leucine zipper, Myc / Myc leucine zipper domain / Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Helix-loop-helix DNA-binding domain / YVTN repeat-like/Quinoprotein amine dehydrogenase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain ...Leucine zipper, Myc / Myc leucine zipper domain / Transcription regulator Myc / Transcription regulator Myc, N-terminal / Myc amino-terminal region / Helix-loop-helix DNA-binding domain / YVTN repeat-like/Quinoprotein amine dehydrogenase / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / 7 Propeller / Methylamine Dehydrogenase; Chain H / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / WD domain, G-beta repeat / WD40リピート / WD40リピート / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 Myc proto-oncogene protein / WD repeat-containing protein 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.898 Å |
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データ登録者 | Sun, Q. / Phan, J. / Olejniczak, E.T. / Thomas, L.R. / Fesik, S.W. / Tansey, W.P. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/Office of the Director | 5DP1OD006933 | 米国 |
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引用 | ジャーナル: Mol.Cell / 年: 2015 タイトル: Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. 著者: Thomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. / Alicie, B. / Howard, G.C. / Cawthon, B. / Ess, K.C. / ...著者: Thomas, L.R. / Wang, Q. / Grieb, B.C. / Phan, J. / Foshage, A.M. / Sun, Q. / Olejniczak, E.T. / Clark, T. / Dey, S. / Lorey, S. / Alicie, B. / Howard, G.C. / Cawthon, B. / Ess, K.C. / Eischen, C.M. / Zhao, Z. / Fesik, S.W. / Tansey, W.P. |
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履歴 | 登録 | 2015年2月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年4月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年5月20日 | Group: Database references |
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改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / Database references ...Author supporting evidence / Database references / Derived calculations / Source and taxonomy カテゴリ: citation / entity_src_gen ...citation / entity_src_gen / pdbx_audit_support / pdbx_entity_src_syn / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ..._citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_entity_src_syn.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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