Entry | Database: PDB / ID: 4q93 |
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Title | Crystal structure of resveratrol bound human tyrosyl tRNA synthetase |
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Components | Tyrosine--tRNA ligase, cytoplasmic |
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Keywords | LIGASE / Resveratrol / Aminoacyl tRNA synthetases / Amino acid activation / active site |
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Function / homology | Function and homology information
methionyl glutamyl tRNA synthetase complex / interleukin-8 receptor binding / tyrosyl-tRNA aminoacylation / tyrosine-tRNA ligase / tyrosine-tRNA ligase activity / Cytosolic tRNA aminoacylation / response to starvation / small molecule binding / tRNA binding / nuclear body ...methionyl glutamyl tRNA synthetase complex / interleukin-8 receptor binding / tyrosyl-tRNA aminoacylation / tyrosine-tRNA ligase / tyrosine-tRNA ligase activity / Cytosolic tRNA aminoacylation / response to starvation / small molecule binding / tRNA binding / nuclear body / apoptotic process / RNA binding / extracellular space / ATP binding / nucleus / cytoplasm / cytosolSimilarity search - Function Tyrosine-tRNA ligase / tRNA-binding domain / Putative tRNA binding domain / tRNA-binding domain profile. / Tyrosyl-Transfer RNA Synthetase / Tyrosyl-Transfer RNA Synthetase / Aminoacyl-tRNA synthetase, class Ic / tRNA synthetases class I (W and Y) / HUPs / Rossmann-like alpha/beta/alpha sandwich fold ...Tyrosine-tRNA ligase / tRNA-binding domain / Putative tRNA binding domain / tRNA-binding domain profile. / Tyrosyl-Transfer RNA Synthetase / Tyrosyl-Transfer RNA Synthetase / Aminoacyl-tRNA synthetase, class Ic / tRNA synthetases class I (W and Y) / HUPs / Rossmann-like alpha/beta/alpha sandwich fold / Nucleic acid-binding, OB-fold / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.1 Å |
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Authors | Mathew, S. / Schimmel, P. |
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Citation | Journal: Nature / Year: 2014 Title: A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Authors: Sajish, M. / Schimmel, P. |
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History | Deposition | Apr 28, 2014 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Dec 17, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 24, 2014 | Group: Structure summary |
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Revision 1.2 | Jan 14, 2015 | Group: Database references |
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Revision 1.3 | Mar 25, 2015 | Group: Database references |
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Revision 1.4 | Jul 17, 2019 | Group: Data collection / Refinement description / Category: software Item: _software.classification / _software.name / _software.version |
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Revision 1.5 | Sep 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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