- PDB-4nft: Crystal structure of human lnkH2B-h2A.Z-Anp32e -
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Basic information
Entry
Database: PDB / ID: 4nft
Title
Crystal structure of human lnkH2B-h2A.Z-Anp32e
Components
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Histone H2B type 2-E, Histone H2A.Z
Keywords
CHAPERONE / Histone binding protein
Function / homology
Function and homology information
phosphatase inhibitor activity / histone chaperone activity / Swr1 complex / RNA polymerase II core promoter sequence-specific DNA binding / heterochromatin / Replacement of protamines by nucleosomes in the male pronucleus / heterochromatin organization / Packaging Of Telomere Ends / protein folding chaperone / Recognition and association of DNA glycosylase with site containing an affected purine ...phosphatase inhibitor activity / histone chaperone activity / Swr1 complex / RNA polymerase II core promoter sequence-specific DNA binding / heterochromatin / Replacement of protamines by nucleosomes in the male pronucleus / heterochromatin organization / Packaging Of Telomere Ends / protein folding chaperone / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / nucleosomal DNA binding / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / RNA Polymerase I Promoter Opening / Assembly of the ORC complex at the origin of replication / DNA methylation / Condensation of Prophase Chromosomes / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / PRC2 methylates histones and DNA / innate immune response in mucosa / Defective pyroptosis / cellular response to estradiol stimulus / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Nonhomologous End-Joining (NHEJ) / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / euchromatin / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / B-WICH complex positively regulates rRNA expression / G2/M DNA damage checkpoint / DNA Damage/Telomere Stress Induced Senescence / chromatin DNA binding / Meiotic recombination / Pre-NOTCH Transcription and Translation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / antimicrobial humoral immune response mediated by antimicrobial peptide / nucleosome / nucleosome assembly / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / chromatin organization / RUNX1 regulates transcription of genes involved in differentiation of HSCs / HATs acetylate histones / Processing of DNA double-strand break ends / histone binding / antibacterial humoral response / Senescence-Associated Secretory Phenotype (SASP) / cytoplasmic vesicle / regulation of apoptotic process / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / Ub-specific processing proteases / defense response to Gram-positive bacterium / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / Amyloid fiber formation / positive regulation of transcription by RNA polymerase II / DNA binding / extracellular space / extracellular exosome / nucleoplasm / nucleus / cytosol Similarity search - Function
A: Histone H2B type 2-E, Histone H2A.Z B: Histone H2B type 2-E, Histone H2A.Z C: Histone H2B type 2-E, Histone H2A.Z D: Histone H2B type 2-E, Histone H2A.Z E: Acidic leucine-rich nuclear phosphoprotein 32 family member E F: Acidic leucine-rich nuclear phosphoprotein 32 family member E
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