Entry Database : PDB / ID : 4n1d Structure visualization Downloads & linksTitle Nodal/BMP2 chimera NB250 ComponentsNodal/BMP2 chimera protein Details Keywords Cytokine / Signaling ProteinFunction / homology Function and homology informationFunction Domain/homology Component
floor plate morphogenesis / left lung morphogenesis / epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification / : / negative regulation of chorionic trophoblast cell proliferation / negative regulation of cell development / type I activin receptor binding / : / polarity specification of proximal/distal axis / : ... floor plate morphogenesis / left lung morphogenesis / epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification / : / negative regulation of chorionic trophoblast cell proliferation / negative regulation of cell development / type I activin receptor binding / : / polarity specification of proximal/distal axis / : / neural fold formation / axial mesodermal cell fate specification / embryonic process involved in female pregnancy / Regulation of signaling by NODAL / : / cardiac atrium formation / cardiocyte differentiation / negative regulation of calcium-independent cell-cell adhesion / cardiac jelly development / negative regulation of aldosterone biosynthetic process / embryonic heart tube anterior/posterior pattern specification / atrioventricular canal morphogenesis / negative regulation of cortisol biosynthetic process / mesenchymal cell proliferation involved in ureteric bud development / mesendoderm development / negative regulation of steroid biosynthetic process / regulation of gastrulation / ameloblast differentiation / morphogen activity / positive regulation of activin receptor signaling pathway / positive regulation of extracellular matrix constituent secretion / negative regulation of cardiac muscle cell differentiation / regulation of odontogenesis of dentin-containing tooth / maternal process involved in parturition / endodermal-mesodermal cell signaling / formation of anatomical boundary / corticotropin hormone secreting cell differentiation / negative regulation of insulin-like growth factor receptor signaling pathway / inhibition of neuroepithelial cell differentiation / thyroid-stimulating hormone-secreting cell differentiation / trophectodermal cellular morphogenesis / mesenchyme development / aortic valve development / cell migration involved in gastrulation / telencephalon regionalization / positive regulation of odontogenesis / positive regulation of phosphatase activity / negative regulation of trophoblast cell migration / maternal placenta development / positive regulation of cartilage development / proteoglycan metabolic process / regulation of stem cell population maintenance / heart induction / positive regulation of peroxisome proliferator activated receptor signaling pathway / pericardium development / lung vasculature development / positive regulation of cell-cell adhesion / BMP receptor complex / co-receptor binding / negative regulation of androgen receptor signaling pathway / telencephalon development / cardiac epithelial to mesenchymal transition / mesenchymal cell differentiation / BMP receptor binding / positive regulation of odontoblast differentiation / endocardial cushion formation / positive regulation of bone mineralization involved in bone maturation / phosphatase activator activity / Transcriptional regulation by RUNX2 / positive regulation of astrocyte differentiation / Signaling by BMP / cellular response to BMP stimulus / cardiac muscle cell differentiation / embryonic pattern specification / SMAD protein signal transduction / cardiac muscle tissue morphogenesis / Signaling by NODAL / positive regulation of ossification / astrocyte differentiation / embryonic cranial skeleton morphogenesis / vasculature development / Molecules associated with elastic fibres / atrioventricular valve morphogenesis / positive regulation of p38MAPK cascade / endocardial cushion morphogenesis / digestive tract morphogenesis / branching involved in ureteric bud morphogenesis / stem cell population maintenance / negative regulation of fat cell differentiation / bone mineralization / heart looping / endodermal cell differentiation / positive regulation of osteoblast proliferation / odontogenesis of dentin-containing tooth / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of SMAD protein signal transduction / inner ear development / cellular response to organic cyclic compound / negative regulation of cell cycle / positive regulation of Wnt signaling pathway Similarity search - Function : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. ... : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.912 Å DetailsAuthors Esquivies, L. CitationJournal : J.Biol.Chem. / Year : 2014Title : Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.Authors : Esquivies, L. / Blackler, A. / Peran, M. / Rodriguez-Esteban, C. / Izpisua Belmonte, J.C. / Booker, E. / Gray, P.C. / Ahn, C. / Kwiatkowski, W. / Choe, S. History Deposition Oct 4, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 4, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Feb 5, 2014 Group : Database referencesRevision 1.2 Jul 26, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / software
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