Entry Database : PDB / ID : 4i0c Structure visualization Downloads & linksTitle The structure of the camelid antibody cAbHuL5 in complex with human lysozyme ComponentsLysozyme C cAbHuL5 antibody DetailsKeywords IMMUNE SYSTEM/HYDROLASE / beta-barrel / alpha-beta protein / immune recognition / glycosidase / IMMUNE SYSTEM-HYDROLASE complexFunction / homology Function and homology informationFunction Domain/homology Component
antimicrobial humoral response / Antimicrobial peptides / specific granule lumen / azurophil granule lumen / tertiary granule lumen / lysozyme / lysozyme activity / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium ... antimicrobial humoral response / Antimicrobial peptides / specific granule lumen / azurophil granule lumen / tertiary granule lumen / lysozyme / lysozyme activity / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function Lysozyme - #10 / Glycoside hydrolase, family 22, lysozyme / Glycoside hydrolase family 22 domain / Glycosyl hydrolases family 22 (GH22) domain signature. / Glycoside hydrolase, family 22 / C-type lysozyme/alpha-lactalbumin family / Glycosyl hydrolases family 22 (GH22) domain profile. / Alpha-lactalbumin / lysozyme C / Lysozyme / Lysozyme-like domain superfamily ... Lysozyme - #10 / Glycoside hydrolase, family 22, lysozyme / Glycoside hydrolase family 22 domain / Glycosyl hydrolases family 22 (GH22) domain signature. / Glycoside hydrolase, family 22 / C-type lysozyme/alpha-lactalbumin family / Glycosyl hydrolases family 22 (GH22) domain profile. / Alpha-lactalbumin / lysozyme C / Lysozyme / Lysozyme-like domain superfamily / Immunoglobulins / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Camelus dromedarius (Arabian camel)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.95 Å DetailsAuthors De Genst, E. / Chan, P.H. / Pardon, E. / Kumita, J.R. / Christodoulou, J. / Menzer, L. / Chirgadze, D.Y. / Robinson, C.V. / Muyldermans, S. / Matagne, A. ...De Genst, E. / Chan, P.H. / Pardon, E. / Kumita, J.R. / Christodoulou, J. / Menzer, L. / Chirgadze, D.Y. / Robinson, C.V. / Muyldermans, S. / Matagne, A. / Wyns, L. / Dobson, C.M. / Dumoulin, M. CitationJournal : J.Phys.Chem.B / Year : 2013Title : A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.Authors : De Genst, E. / Chan, P.H. / Pardon, E. / Hsu, S.T. / Kumita, J.R. / Christodoulou, J. / Menzer, L. / Chirgadze, D.Y. / Robinson, C.V. / Muyldermans, S. / Matagne, A. / Wyns, L. / Dobson, C.M. / Dumoulin, M. History Deposition Nov 16, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 9, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Nov 6, 2013 Group : Database references
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