Entry | Database: PDB / ID: 4ekx |
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Title | Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 |
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Components | - 14L protein
- Interleukin-18
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Keywords | CYTOKINE/Viral protein / Binding Protein / beta trefoil / Immunoglobulin fold / YLDV / Yaba / yatapoxvirus / 14L / Cytokine Signaling / CYTOKINE-Viral protein complex |
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Function / homology | Function and homology information
interleukin-18 receptor binding / Interleukin-18 signaling / positive regulation of tissue remodeling / positive regulation of T-helper 2 cell differentiation / positive regulation of T-helper 1 cell cytokine production / positive regulation of macrophage derived foam cell differentiation / neutrophil activation / positive regulation of interleukin-13 production / positive regulation of neuroinflammatory response / interleukin-18-mediated signaling pathway ...interleukin-18 receptor binding / Interleukin-18 signaling / positive regulation of tissue remodeling / positive regulation of T-helper 2 cell differentiation / positive regulation of T-helper 1 cell cytokine production / positive regulation of macrophage derived foam cell differentiation / neutrophil activation / positive regulation of interleukin-13 production / positive regulation of neuroinflammatory response / interleukin-18-mediated signaling pathway / negative regulation of myoblast differentiation / type 2 immune response / natural killer cell activation / sleep / Interleukin-1 processing / positive regulation of NK T cell proliferation / triglyceride homeostasis / positive regulation of natural killer cell proliferation / positive regulation of granulocyte macrophage colony-stimulating factor production / natural killer cell mediated cytotoxicity / T-helper 1 type immune response / positive regulation of activated T cell proliferation / positive regulation of interleukin-17 production / Interleukin-10 signaling / establishment of skin barrier / Pyroptosis / regulation of cell adhesion / Purinergic signaling in leishmaniasis infection / positive regulation of chemokine production / positive regulation of tyrosine phosphorylation of STAT protein / cholesterol homeostasis / cytokine activity / positive regulation of smooth muscle cell proliferation / positive regulation of inflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / positive regulation of type II interferon production / cell-cell signaling / positive regulation of cold-induced thermogenesis / positive regulation of NF-kappaB transcription factor activity / peptidase activity / Interleukin-4 and Interleukin-13 signaling / angiogenesis / cell population proliferation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / defense response to Gram-positive bacterium / inflammatory response / protein serine/threonine kinase activity / positive regulation of transcription by RNA polymerase II / proteolysis / extracellular space / extracellular region / cytosolSimilarity search - Function Interleukin-18 / Interleukin-1 family / Interleukin-1 / 18 / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like ...Interleukin-18 / Interleukin-1 family / Interleukin-1 / 18 / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Yaba-like disease virus
Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / molecular replacement / Resolution: 1.75 Å |
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Authors | Krumm, B.E. / Xiang, Y. / Deng, J. |
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Citation | Journal: Plos Pathog. / Year: 2012 Title: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Authors: Krumm, B. / Meng, X. / Wang, Z. / Xiang, Y. / Deng, J. |
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History | Deposition | Apr 10, 2012 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 26, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 3, 2012 | Group: Data collection |
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Revision 1.2 | Nov 15, 2017 | Group: Advisory / Refinement description / Category: pdbx_unobs_or_zero_occ_atoms / software |
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