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- PDB-4kn2: Human folate receptor beta (FOLR2) in complex with antifolate pem... -
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Basic information
Entry | Database: PDB / ID: 4kn2 | ||||||
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Title | Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed | ||||||
![]() | Folate receptor beta | ||||||
![]() | MEMBRANE PROTEIN / Folate Receptor Beta / FOLR2 / folate receptor / Folic acid / folates / 5-methyltetrahydrofolate / antifolates / folate-conjugates / GPI-anchored protein on eukaryotic membrane / TRANSPORT PROTEIN | ||||||
Function / homology | ![]() folic acid receptor activity / folic acid transport / sperm-egg recognition / fusion of sperm to egg plasma membrane involved in single fertilization / Post-translational modification: synthesis of GPI-anchored proteins / Metabolism of folate and pterines / folic acid binding / signaling receptor activity / cell adhesion / inflammatory response ...folic acid receptor activity / folic acid transport / sperm-egg recognition / fusion of sperm to egg plasma membrane involved in single fertilization / Post-translational modification: synthesis of GPI-anchored proteins / Metabolism of folate and pterines / folic acid binding / signaling receptor activity / cell adhesion / inflammatory response / external side of plasma membrane / positive regulation of cell population proliferation / cell surface / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Wibowo, A.S. / Dann III, C.E. | ||||||
![]() | ![]() Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Authors: Wibowo, A.S. / Singh, M. / Reeder, K.M. / Carter, J.J. / Kovach, A.R. / Meng, W. / Ratnam, M. / Zhang, F. / Dann, C.E. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 262.4 KB | Display | ![]() |
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PDB format | ![]() | 213.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 4km6C ![]() 4km7C ![]() 4kmxC ![]() 4kmyC ![]() 4kmzSC ![]() 4kn0C ![]() 4kn1C C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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