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Yorodumi- PDB-4kn2: Human folate receptor beta (FOLR2) in complex with antifolate pem... -
+Open data
-Basic information
Entry | Database: PDB / ID: 4kn2 | ||||||
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Title | Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed | ||||||
Components | Folate receptor beta | ||||||
Keywords | MEMBRANE PROTEIN / Folate Receptor Beta / FOLR2 / folate receptor / Folic acid / folates / 5-methyltetrahydrofolate / antifolates / folate-conjugates / GPI-anchored protein on eukaryotic membrane / TRANSPORT PROTEIN | ||||||
Function / homology | Function and homology information folic acid receptor activity / folic acid transport / sperm-egg recognition / fusion of sperm to egg plasma membrane involved in single fertilization / Post-translational modification: synthesis of GPI-anchored proteins / Metabolism of folate and pterines / folic acid binding / signaling receptor activity / cell adhesion / inflammatory response ...folic acid receptor activity / folic acid transport / sperm-egg recognition / fusion of sperm to egg plasma membrane involved in single fertilization / Post-translational modification: synthesis of GPI-anchored proteins / Metabolism of folate and pterines / folic acid binding / signaling receptor activity / cell adhesion / inflammatory response / external side of plasma membrane / positive regulation of cell population proliferation / cell surface / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å | ||||||
Authors | Wibowo, A.S. / Dann III, C.E. | ||||||
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2013 Title: Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Authors: Wibowo, A.S. / Singh, M. / Reeder, K.M. / Carter, J.J. / Kovach, A.R. / Meng, W. / Ratnam, M. / Zhang, F. / Dann, C.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4kn2.cif.gz | 262.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb4kn2.ent.gz | 213.3 KB | Display | PDB format |
PDBx/mmJSON format | 4kn2.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 4kn2_validation.pdf.gz | 1.1 MB | Display | wwPDB validaton report |
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Full document | 4kn2_full_validation.pdf.gz | 1.1 MB | Display | |
Data in XML | 4kn2_validation.xml.gz | 25.9 KB | Display | |
Data in CIF | 4kn2_validation.cif.gz | 34.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/kn/4kn2 ftp://data.pdbj.org/pub/pdb/validation_reports/kn/4kn2 | HTTPS FTP |
-Related structure data
Related structure data | 4km6C 4km7C 4kmxC 4kmyC 4kmzSC 4kn0C 4kn1C C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
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-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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