- PDB-4kbs: Crystal structure of human ceramide-1-phosphate transfer protein ... -
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基本情報
登録情報
データベース: PDB / ID: 4kbs
タイトル
Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 12:0 phosphatidic acid (12:0 PA)
要素
Glycolipid transfer protein domain-containing protein 1
キーワード
LIPID TRANSPORT / Lipid transfer protein / GLTP-fold / CPTP / C1P / Ceramide-1-phosphate / Protein-lipid complex / Eicosanoid
機能・相同性
機能・相同性情報
ceramide 1-phosphate transport / ceramide transport / ceramide 1-phosphate binding / ceramide 1-phosphate transfer activity / Glycosphingolipid transport / intermembrane lipid transfer / negative regulation of NLRP3 inflammasome complex assembly / nuclear outer membrane / negative regulation of interleukin-1 beta production / negative regulation of autophagy ...ceramide 1-phosphate transport / ceramide transport / ceramide 1-phosphate binding / ceramide 1-phosphate transfer activity / Glycosphingolipid transport / intermembrane lipid transfer / negative regulation of NLRP3 inflammasome complex assembly / nuclear outer membrane / negative regulation of interleukin-1 beta production / negative regulation of autophagy / phospholipid binding / endosome membrane / Golgi apparatus / plasma membrane / cytosol 類似検索 - 分子機能
Glycolipid transfer protein domain / Glycolipid transfer protein superfamily / Glycolipid transfer protein (GLTP) / Glycolipid transfer protein, GLTP / Glycolipid transfer protein / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE / Ceramide-1-phosphate transfer protein 類似検索 - 構成要素
構造決定の手法: 分子置換 開始モデル: Human ceramide-1-phosphate transfer protein in complex with 2:0 Ceramide-1-phosphate (2:0 C1P) 解像度: 1.898→32.622 Å / Occupancy max: 1 / Occupancy min: 0.01 / SU ML: 0.23 / 交差検証法: THROUGHOUT / σ(F): 0.12 / 位相誤差: 22.55 / 立体化学のターゲット値: ML
Rfactor
反射数
%反射
Selection details
Rfree
0.2337
1946
6.27 %
Random
Rwork
0.1884
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obs
0.1913
31035
96.84 %
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溶媒の処理
減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL / Bsol: 46.36 Å2 / ksol: 0.333 e/Å3