登録情報 データベース : PDB / ID : 4c02 構造の表示 ダウンロードとリンクタイトル Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin 要素ACTIVIN RECEPTOR TYPE-1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B 詳細キーワード TRANSFERASE/ISOMERASE / TRANSFERASE-ISOMERASE COMPLEX / TRANSFERASE / DORSOMORPHIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
endocardial cushion cell fate commitment / mitral valve morphogenesis / endocardial cushion fusion / BMP receptor complex / BMP receptor activity / atrial septum primum morphogenesis / cardiac muscle cell fate commitment / acute inflammatory response / activin receptor activity, type I / positive regulation of cardiac epithelial to mesenchymal transition ... endocardial cushion cell fate commitment / mitral valve morphogenesis / endocardial cushion fusion / BMP receptor complex / BMP receptor activity / atrial septum primum morphogenesis / cardiac muscle cell fate commitment / acute inflammatory response / activin receptor activity, type I / positive regulation of cardiac epithelial to mesenchymal transition / positive regulation of determination of dorsal identity / transforming growth factor beta receptor activity, type I / activin receptor complex / endocardial cushion formation / smooth muscle cell differentiation / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / pharyngeal system development / activin binding / cellular response to BMP stimulus / activin receptor signaling pathway / negative regulation of activin receptor signaling pathway / positive regulation of sequestering of calcium ion / cyclic nucleotide binding / negative regulation of calcium-mediated signaling / transforming growth factor beta binding / embryonic heart tube morphogenesis / negative regulation of insulin secretion involved in cellular response to glucose stimulus / gastrulation with mouth forming second / dorsal/ventral pattern formation / negative regulation of release of sequestered calcium ion into cytosol / neuronal action potential propagation / insulin secretion involved in cellular response to glucose stimulus / determination of left/right symmetry / neural crest cell migration / response to redox state / atrioventricular valve morphogenesis / protein maturation by protein folding / 'de novo' protein folding / negative regulation of heart rate / branching involved in blood vessel morphogenesis / negative regulation of G1/S transition of mitotic cell cycle / ventricular septum morphogenesis / FK506 binding / positive regulation of axon regeneration / channel regulator activity / SMAD binding / germ cell development / peptide hormone binding / positive regulation of SMAD protein signal transduction / mesoderm formation / smooth muscle contraction / regulation of ossification / response to vitamin E / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / calcium channel inhibitor activity / BMP signaling pathway / positive regulation of osteoblast differentiation / positive regulation of bone mineralization / negative regulation of signal transduction / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / T cell proliferation / release of sequestered calcium ion into cytosol / Ion homeostasis / regulation of cytosolic calcium ion concentration / sarcoplasmic reticulum membrane / calcium channel complex / transforming growth factor beta receptor signaling pathway / protein tyrosine kinase binding / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / negative regulation of extrinsic apoptotic signaling pathway / calcium-mediated signaling / response to hydrogen peroxide / Stimuli-sensing channels / cellular response to growth factor stimulus / Z disc / positive regulation of peptidyl-tyrosine phosphorylation / apical part of cell / heart development / positive regulation of cytosolic calcium ion concentration / protein refolding / in utero embryonic development / transmembrane transporter binding / protein kinase activity / positive regulation of cell migration / cadherin binding / signaling receptor binding / protein serine/threonine kinase activity / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / ATP binding / membrane / metal ion binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Activin types I and II receptor domain / Activin types I and II receptor domain / Ser/Thr protein kinase, TGFB receptor / Chitinase A; domain 3 - #40 / : / Snake toxin-like superfamily ... GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Activin types I and II receptor domain / Activin types I and II receptor domain / Ser/Thr protein kinase, TGFB receptor / Chitinase A; domain 3 - #40 / : / Snake toxin-like superfamily / Chitinase A; domain 3 / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase / Peptidyl-prolyl cis-trans isomerase domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 CITRATE ANION / Chem-TAK / Peptidyl-prolyl cis-trans isomerase FKBP1B / Activin receptor type-1 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.17 Å 詳細データ登録者 Williams, E. / Riesebos, E. / Vollmar, M. / Krojer, T. / Bradley, A. / Shrestha, L. / Kupinska, K. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. ...Williams, E. / Riesebos, E. / Vollmar, M. / Krojer, T. / Bradley, A. / Shrestha, L. / Kupinska, K. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. 引用ジャーナル : Ph D Thesis タイトル : Crystal Structure of Human Acvr1 (Alk2) in Complex with Fkbp12.6 And Dorsomorphin著者 : Williams, E. / Riesebos, E. / Vollmar, M. / Krojer, T. / Bradley, A. / Shrestha, L. / Kupinska, K. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. 履歴 登録 2013年7月31日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年8月7日 Provider : repository / タイプ : Initial release改定 1.1 2018年1月24日 Group : Database references / カテゴリ : citation_author / Item : _citation_author.name改定 2.0 2021年2月10日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Other / Structure summary カテゴリ : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / pdbx_database_status / pdbx_poly_seq_scheme / pdbx_struct_sheet_hbond / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_torsion / struct_conf / struct_ref_seq / struct_sheet_range / struct_site / struct_site_gen Item : _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id ... _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id / _pdbx_database_status.status_code_sf / _pdbx_poly_seq_scheme.pdb_seq_num / _pdbx_struct_sheet_hbond.range_1_auth_seq_id / _pdbx_struct_sheet_hbond.range_2_auth_seq_id / _pdbx_unobs_or_zero_occ_atoms.auth_seq_id / _pdbx_validate_torsion.auth_seq_id / _struct_conf.beg_auth_seq_id / _struct_conf.end_auth_seq_id / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_sheet_range.beg_auth_seq_id / _struct_sheet_range.end_auth_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id / _struct_site_gen.auth_seq_id 改定 2.1 2023年12月20日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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