Entry Database : PDB / ID : 3pds Structure visualization Downloads & linksTitle Irreversible Agonist-Beta2 Adrenoceptor Complex ComponentsFusion protein Beta-2 adrenergic receptor/Lysozyme Details Keywords Membrane Protein/Hydrolase / GPCR / signaling / beta adrenergic agonist / fusion protein / Membrane Protein-Hydrolase complexFunction / homology Function and homology informationFunction Domain/homology Component
beta2-adrenergic receptor activity / norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure / positive regulation of mini excitatory postsynaptic potential / positive regulation of cAMP-dependent protein kinase activity / positive regulation of AMPA receptor activity / norepinephrine binding / positive regulation of autophagosome maturation / heat generation / Adrenoceptors / activation of transmembrane receptor protein tyrosine kinase activity ... beta2-adrenergic receptor activity / norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure / positive regulation of mini excitatory postsynaptic potential / positive regulation of cAMP-dependent protein kinase activity / positive regulation of AMPA receptor activity / norepinephrine binding / positive regulation of autophagosome maturation / heat generation / Adrenoceptors / activation of transmembrane receptor protein tyrosine kinase activity / negative regulation of smooth muscle contraction / positive regulation of lipophagy / negative regulation of multicellular organism growth / negative regulation of G protein-coupled receptor signaling pathway / response to psychosocial stress / endosome to lysosome transport / adrenergic receptor signaling pathway / diet induced thermogenesis / positive regulation of protein kinase A signaling / neuronal dense core vesicle / adenylate cyclase binding / smooth muscle contraction / bone resorption / potassium channel regulator activity / positive regulation of bone mineralization / brown fat cell differentiation / adenylate cyclase-activating adrenergic receptor signaling pathway / regulation of sodium ion transport / viral release from host cell by cytolysis / response to cold / peptidoglycan catabolic process / receptor-mediated endocytosis / clathrin-coated endocytic vesicle membrane / positive regulation of protein serine/threonine kinase activity / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / cellular response to amyloid-beta / cell wall macromolecule catabolic process / Cargo recognition for clathrin-mediated endocytosis / lysozyme / lysozyme activity / positive regulation of cold-induced thermogenesis / Clathrin-mediated endocytosis / amyloid-beta binding / G alpha (s) signalling events / host cell cytoplasm / transcription by RNA polymerase II / positive regulation of MAPK cascade / lysosome / early endosome / receptor complex / cell surface receptor signaling pathway / endosome membrane / Ub-specific processing proteases / endosome / defense response to bacterium / apical plasma membrane / protein-containing complex binding / Golgi apparatus / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / identical protein binding / membrane / nucleus / plasma membrane Similarity search - Function Beta 2 adrenoceptor / Adrenoceptor family / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / : / Glycoside hydrolase, family 24 / Phage lysozyme ... Beta 2 adrenoceptor / Adrenoceptor family / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / : / Glycoside hydrolase, family 24 / Phage lysozyme / Lysozyme domain superfamily / Serpentine type 7TM GPCR chemoreceptor Srsx / Lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human) Enterobacteria phage T4 (virus)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.5 Å DetailsAuthors Rosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.-J. / DeVree, B.T. / Sunahara, R.K. ...Rosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.-J. / DeVree, B.T. / Sunahara, R.K. / Chae, P.S. / Gellman, S.H. / Dror, R.O. / Shaw, D.E. / Weis, W.I. / Caffrey, M. / Gmeiner, P. / Kobilka, B.K. CitationJournal : Nature / Year : 2011Title : Structure and function of an irreversible agonist-beta(2) adrenoceptor complexAuthors: Rosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.J. / Devree, B.T. / Sunahara, R.K. / Chae, P.S. / Gellman, S.H. / Dror, R.O. / ... Authors : Rosenbaum, D.M. / Zhang, C. / Lyons, J.A. / Holl, R. / Aragao, D. / Arlow, D.H. / Rasmussen, S.G.F. / Choi, H.J. / Devree, B.T. / Sunahara, R.K. / Chae, P.S. / Gellman, S.H. / Dror, R.O. / Shaw, D.E. / Weis, W.I. / Caffrey, M. / Gmeiner, P. / Kobilka, B.K. History Deposition Oct 24, 2010 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 12, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Jul 26, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Mar 29, 2023 Group : Database references / Derived calculations / Structure summaryCategory : audit_author / citation_author ... audit_author / citation_author / database_2 / struct_conn / struct_ref_seq_dif / struct_site Item : _audit_author.identifier_ORCID / _citation_author.identifier_ORCID ... _audit_author.identifier_ORCID / _citation_author.identifier_ORCID / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Sep 20, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_modelRevision 1.5 Oct 30, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature
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