- PDB-3pc8: X-ray crystal structure of the heterodimeric complex of XRCC1 and... -
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Basic information
Entry
Database: PDB / ID: 3pc8
Title
X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains.
Components
DNA ligase 3
DNA repair protein XRCC1
Keywords
DNA BINDING PROTEIN/LIGASE / DNA repair / BRCT domain / Protein:protein interactions / DNA BINDING PROTEIN - LIGASE complex / DNA BINDING PROTEIN-LIGASE complex
Function / homology
Function and homology information
Resolution of AP sites via the single-nucleotide replacement pathway / HDR through MMEJ (alt-NHEJ) / DNA ligase III-XRCC1 complex / negative regulation of mitochondrial DNA replication / oxidized DNA binding / telomeric DNA-containing double minutes formation / ERCC4-ERCC1 complex / negative regulation of protection from non-homologous end joining at telomere / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / ADP-D-ribose modification-dependent protein binding ...Resolution of AP sites via the single-nucleotide replacement pathway / HDR through MMEJ (alt-NHEJ) / DNA ligase III-XRCC1 complex / negative regulation of mitochondrial DNA replication / oxidized DNA binding / telomeric DNA-containing double minutes formation / ERCC4-ERCC1 complex / negative regulation of protection from non-homologous end joining at telomere / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / ADP-D-ribose modification-dependent protein binding / Gap-filling DNA repair synthesis and ligation in TC-NER / negative regulation of protein ADP-ribosylation / base-excision repair, DNA ligation / DNA ligase activity / poly-ADP-D-ribose binding / DNA ligase (ATP) / positive regulation of single strand break repair / DNA ligase (ATP) activity / voluntary musculoskeletal movement / cerebellum morphogenesis / single strand break repair / replication-born double-strand break repair via sister chromatid exchange / DNA ligation / HDR through MMEJ (alt-NHEJ) / lagging strand elongation / response to hydroperoxide / mitochondrial DNA repair / Resolution of AP sites via the single-nucleotide replacement pathway / DNA biosynthetic process / double-strand break repair via alternative nonhomologous end joining / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / site of DNA damage / : / base-excision repair, gap-filling / Gap-filling DNA repair synthesis and ligation in GG-NER / mitochondrion organization / hippocampus development / double-strand break repair via homologous recombination / base-excision repair / double-strand break repair via nonhomologous end joining / Gap-filling DNA repair synthesis and ligation in TC-NER / double-strand break repair / chromosome, telomeric region / response to hypoxia / response to xenobiotic stimulus / cell division / DNA repair / chromatin / nucleolus / enzyme binding / mitochondrion / DNA binding / zinc ion binding / nucleoplasm / ATP binding / nucleus Similarity search - Function
DNA ligase 3, BRCT domain / DNA ligase 3 BRCT domain / DNA-repair protein Xrcc1, N-terminal / XRCC1, first (central) BRCT domain / XRCC1 N terminal domain / : / DNA ligase, ATP-dependent / DNA ligase, ATP-dependent, N-terminal / DNA ligase, ATP-dependent, N-terminal domain superfamily / DNA ligase N terminus ...DNA ligase 3, BRCT domain / DNA ligase 3 BRCT domain / DNA-repair protein Xrcc1, N-terminal / XRCC1, first (central) BRCT domain / XRCC1 N terminal domain / : / DNA ligase, ATP-dependent / DNA ligase, ATP-dependent, N-terminal / DNA ligase, ATP-dependent, N-terminal domain superfamily / DNA ligase N terminus / ATP-dependent DNA ligase signature 2. / ATP-dependent DNA ligase AMP-binding site. / DNA ligase, ATP-dependent, C-terminal / ATP dependent DNA ligase C terminal region / DNA ligase, ATP-dependent, conserved site / ATP-dependent DNA ligase family profile. / BRCT domain / Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. / Zinc finger, PARP-type superfamily / Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region / Zinc finger poly(ADP-ribose) polymerase (PARP)-type profile. / Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region / DNA ligase, ATP-dependent, central / ATP dependent DNA ligase domain / Zinc finger, PARP-type / BRCT domain, a BRCA1 C-terminus domain / BRCA1 C Terminus (BRCT) domain / breast cancer carboxy-terminal domain / BRCT domain profile. / BRCT domain / BRCT domain superfamily / Galactose-binding-like domain superfamily / Nucleic acid-binding, OB-fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology