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Yorodumi- PDB-3pc8: X-ray crystal structure of the heterodimeric complex of XRCC1 and... -
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-Basic information
Entry | Database: PDB / ID: 3pc8 | ||||||
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Title | X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains. | ||||||
Components |
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Keywords | DNA BINDING PROTEIN/LIGASE / DNA repair / BRCT domain / Protein:protein interactions / DNA BINDING PROTEIN - LIGASE complex / DNA BINDING PROTEIN-LIGASE complex | ||||||
Function / homology | Function and homology information Resolution of AP sites via the single-nucleotide replacement pathway / HDR through MMEJ (alt-NHEJ) / DNA ligase III-XRCC1 complex / negative regulation of mitochondrial DNA replication / oxidized DNA binding / telomeric DNA-containing double minutes formation / ERCC4-ERCC1 complex / negative regulation of protection from non-homologous end joining at telomere / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / ADP-D-ribose modification-dependent protein binding ...Resolution of AP sites via the single-nucleotide replacement pathway / HDR through MMEJ (alt-NHEJ) / DNA ligase III-XRCC1 complex / negative regulation of mitochondrial DNA replication / oxidized DNA binding / telomeric DNA-containing double minutes formation / ERCC4-ERCC1 complex / negative regulation of protection from non-homologous end joining at telomere / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / ADP-D-ribose modification-dependent protein binding / Gap-filling DNA repair synthesis and ligation in TC-NER / negative regulation of protein ADP-ribosylation / base-excision repair, DNA ligation / DNA ligase activity / poly-ADP-D-ribose binding / DNA ligase (ATP) / positive regulation of single strand break repair / DNA ligase (ATP) activity / voluntary musculoskeletal movement / cerebellum morphogenesis / single strand break repair / replication-born double-strand break repair via sister chromatid exchange / DNA ligation / HDR through MMEJ (alt-NHEJ) / lagging strand elongation / response to hydroperoxide / mitochondrial DNA repair / Resolution of AP sites via the single-nucleotide replacement pathway / DNA biosynthetic process / double-strand break repair via alternative nonhomologous end joining / APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway / site of DNA damage / mitochondrion organization / Gap-filling DNA repair synthesis and ligation in GG-NER / base-excision repair, gap-filling / : / hippocampus development / double-strand break repair via homologous recombination / base-excision repair / double-strand break repair via nonhomologous end joining / Gap-filling DNA repair synthesis and ligation in TC-NER / double-strand break repair / chromosome, telomeric region / response to hypoxia / response to xenobiotic stimulus / cell cycle / cell division / DNA repair / chromatin / nucleolus / enzyme binding / mitochondrion / DNA binding / zinc ion binding / nucleoplasm / ATP binding / nucleus Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.31 Å | ||||||
Authors | Cuneo, M.J. / Krahn, J.M. / London, R.E. | ||||||
Citation | Journal: Nucleic Acids Res. / Year: 2011 Title: The structural basis for partitioning of the XRCC1/DNA ligase III-{alpha} BRCT-mediated dimer complexes. Authors: Cuneo, M.J. / Gabel, S.A. / Krahn, J.M. / Ricker, M.A. / London, R.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3pc8.cif.gz | 164.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3pc8.ent.gz | 129.7 KB | Display | PDB format |
PDBx/mmJSON format | 3pc8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3pc8_validation.pdf.gz | 461.1 KB | Display | wwPDB validaton report |
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Full document | 3pc8_full_validation.pdf.gz | 463 KB | Display | |
Data in XML | 3pc8_validation.xml.gz | 16.9 KB | Display | |
Data in CIF | 3pc8_validation.cif.gz | 23.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pc/3pc8 ftp://data.pdbj.org/pub/pdb/validation_reports/pc/3pc8 | HTTPS FTP |
-Related structure data
-Links
-Assembly
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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