Entry Database : PDB / ID : 3kmz Structure visualization Downloads & linksTitle Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment ComponentsNuclear receptor corepressor 1 Retinoic acid receptor alpha DetailsKeywords TRANSCRIPTION / nuclear receptor transcription factor ligand binding domain / DNA-binding / Metal-binding / Nucleus / Phosphoprotein / Proto-oncogene / Receptor / Transcription regulation / Zinc-finger / Chromatin regulator / RepressorFunction / homology Function and homology informationFunction Domain/homology Component
Sertoli cell fate commitment / positive regulation of binding / NR1D1 (REV-ERBA) represses gene expression / trachea cartilage development / ventricular cardiac muscle cell differentiation / embryonic camera-type eye development / chondroblast differentiation / glandular epithelial cell development / Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of granulocyte differentiation ... Sertoli cell fate commitment / positive regulation of binding / NR1D1 (REV-ERBA) represses gene expression / trachea cartilage development / ventricular cardiac muscle cell differentiation / embryonic camera-type eye development / chondroblast differentiation / glandular epithelial cell development / Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of granulocyte differentiation / protein kinase B binding / cellular response to corticotropin-releasing hormone stimulus / growth plate cartilage development / positive regulation of T-helper 2 cell differentiation / prostate gland development / negative regulation of cartilage development / negative regulation of androgen receptor signaling pathway / retinoic acid-responsive element binding / regulation of hematopoietic progenitor cell differentiation / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / nuclear glucocorticoid receptor binding / negative regulation of JNK cascade / retinoic acid binding / response to vitamin A / negative regulation of glycolytic process / apoptotic cell clearance / limb development / nuclear thyroid hormone receptor binding / regulation of myelination / protein kinase A binding / ureteric bud development / Signaling by Retinoic Acid / DNA-binding transcription repressor activity / negative regulation of fatty acid metabolic process / heterocyclic compound binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / Notch-HLH transcription pathway / positive regulation of interleukin-4 production / face development / alpha-actinin binding / germ cell development / locomotor rhythm / histone deacetylase complex / Regulation of MECP2 expression and activity / negative regulation of type II interferon production / negative regulation of tumor necrosis factor production / retinoic acid receptor signaling pathway / spindle assembly / cellular response to estrogen stimulus / positive regulation of cell cycle / cellular response to retinoic acid / response to retinoic acid / Nuclear signaling by ERBB4 / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / transcription repressor complex / positive regulation of neuron differentiation / Regulation of lipid metabolism by PPARalpha / hormone-mediated signaling pathway / mRNA regulatory element binding translation repressor activity / negative regulation of miRNA transcription / liver development / response to cytokine / neural tube closure / HDACs deacetylate histones / female pregnancy / hippocampus development / nuclear receptor binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Heme signaling / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / regulation of synaptic plasticity / Transcriptional activation of mitochondrial biogenesis / multicellular organism growth / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / chromatin DNA binding / mitotic spindle / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / mRNA 5'-UTR binding / transcription coactivator binding / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Nuclear Receptor transcription pathway / HCMV Early Events / Transcriptional regulation of granulopoiesis / RNA polymerase II transcription regulator complex / transcription corepressor activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / Circadian Clock / actin cytoskeleton / response to estradiol / chromatin organization / cellular response to lipopolysaccharide Similarity search - Function : / : / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / Retinoic acid receptor / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains ... : / : / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / Retinoic acid receptor / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Retinoid X Receptor / Retinoid X Receptor / Homeobox-like domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Bourguet, W. / le Maire, A. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2010Title : A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.Authors : le Maire, A. / Teyssier, C. / Erb, C. / Grimaldi, M. / Alvarez, S. / de Lera, A.R. / Balaguer, P. / Gronemeyer, H. / Royer, C.A. / Germain, P. / Bourguet, W. History Deposition Nov 11, 2009 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 2, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Sep 6, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.3 Nov 22, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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