登録情報 データベース : PDB / ID : 3kfd 構造の表示 ダウンロードとリンクタイトル Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 要素TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 詳細キーワード CYTOKINE/CYTOKINE RECEPTOR / TGF-beta / TGF-b1 / TGF-beta receptor type-1 / TGF-beta receptor type-2 / TbRII / TbRI / Growth factor / Receptor / Serine/threonine-protein kinase / CYTOKINE-CYTOKINE RECEPTOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of tolerance induction to self antigen / positive regulation of B cell tolerance induction / inferior endocardial cushion morphogenesis / transforming growth factor beta receptor activity, type II / bronchus morphogenesis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / regulation of branching involved in mammary gland duct morphogenesis / mammary gland morphogenesis ... positive regulation of tolerance induction to self antigen / positive regulation of B cell tolerance induction / inferior endocardial cushion morphogenesis / transforming growth factor beta receptor activity, type II / bronchus morphogenesis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / regulation of branching involved in mammary gland duct morphogenesis / mammary gland morphogenesis / positive regulation of microglia differentiation / Influenza Virus Induced Apoptosis / lens fiber cell apoptotic process / frontal suture morphogenesis / growth plate cartilage chondrocyte growth / negative regulation of skeletal muscle tissue development / tricuspid valve morphogenesis / regulation of enamel mineralization / regulatory T cell differentiation / regulation of cartilage development / TGFBR2 MSI Frameshift Mutants in Cancer / activin receptor activity / extracellular structure organization / epicardium morphogenesis / regulation of blood vessel remodeling / tolerance induction to self antigen / regulation of striated muscle tissue development / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / miRNA transport / regulation of protein import into nucleus / embryonic liver development / columnar/cuboidal epithelial cell maturation / parathyroid gland development / type III transforming growth factor beta receptor binding / transforming growth factor beta ligand-receptor complex / positive regulation of odontogenesis / Langerhans cell differentiation / negative regulation of hyaluronan biosynthetic process / regulation of cardiac muscle cell proliferation / positive regulation of tight junction disassembly / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / aorta morphogenesis / positive regulation of receptor signaling pathway via STAT / connective tissue replacement involved in inflammatory response wound healing / positive regulation of exit from mitosis / extracellular matrix assembly / positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / negative regulation of macrophage cytokine production / odontoblast differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of smooth muscle cell differentiation / transforming growth factor beta receptor activity / positive regulation of isotype switching to IgA isotypes / secondary palate development / positive regulation of mesenchymal stem cell proliferation / cardiac left ventricle morphogenesis / ventricular compact myocardium morphogenesis / mammary gland branching involved in thelarche / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / membrane protein intracellular domain proteolysis / heart valve morphogenesis / endocardial cushion fusion / positive regulation of T cell tolerance induction / retina vasculature development in camera-type eye / membranous septum morphogenesis / response to laminar fluid shear stress / positive regulation of primary miRNA processing / lung lobe morphogenesis / positive regulation of NK T cell differentiation / positive regulation of vasculature development / regulation of epithelial to mesenchymal transition / bronchiole development / hyaluronan catabolic process / activin receptor activity, type I / regulation of transforming growth factor beta receptor signaling pathway / cardiac epithelial to mesenchymal transition / mesenchymal cell differentiation / transforming growth factor beta receptor activity, type I / activin receptor complex / neuron fate commitment / ATP biosynthetic process / receptor catabolic process / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of extracellular matrix assembly / lens fiber cell differentiation / negative regulation of extracellular matrix disassembly / type II transforming growth factor beta receptor binding / regulation of stem cell proliferation / TGFBR1 LBD Mutants in Cancer / oligodendrocyte development / myeloid dendritic cell differentiation / receptor protein serine/threonine kinase / germ cell migration / angiogenesis involved in coronary vascular morphogenesis / response to salt / transmembrane receptor protein serine/threonine kinase activity / pharyngeal system development / negative regulation of biomineral tissue development 類似検索 - 分子機能 Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor-beta receptor, type II / Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related ... Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor-beta receptor, type II / Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Ribbon / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 Transforming growth factor beta-1 proprotein / TGF-beta receptor type-1 / TGF-beta receptor type-2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.995 Å 詳細データ登録者 Radaev, S. / Sun, P.D. 引用ジャーナル : J.Biol.Chem. / 年 : 2010タイトル : Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.著者 : Radaev, S. / Zou, Z. / Huang, T. / Lafer, E.M. / Hinck, A.P. / Sun, P.D. 履歴 登録 2009年10月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2010年3月2日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年9月6日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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