Entry Database : PDB / ID : 3ejj Structure visualization Downloads & linksTitle Structure of M-CSF bound to the first three domains of FMS ComponentsColony stimulating factor-1 Macrophage colony-stimulating factor 1 receptor DetailsKeywords CYTOKINE/SIGNALING PROTEIN / growth factor-receptor complex / receptor tyrosine kinase / cytokine / 4-helix bundle / ATP-binding / Glycoprotein / Immunoglobulin domain / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / Receptor / Transferase / Transmembrane / Tyrosine-protein kinase / CYTOKINE-SIGNALING PROTEIN COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of protein metabolic process => GO:0051247 / regulation of mononuclear cell proliferation / negative regulation of platelet formation / Other interleukin signaling / mammary gland fat development / positive regulation of macrophage colony-stimulating factor signaling pathway / macrophage homeostasis / positive regulation of astrocyte activation / macrophage colony-stimulating factor receptor binding / monocyte homeostasis ... positive regulation of protein metabolic process => GO:0051247 / regulation of mononuclear cell proliferation / negative regulation of platelet formation / Other interleukin signaling / mammary gland fat development / positive regulation of macrophage colony-stimulating factor signaling pathway / macrophage homeostasis / positive regulation of astrocyte activation / macrophage colony-stimulating factor receptor binding / monocyte homeostasis / osteoclast proliferation / positive regulation of macrophage migration / : / developmental process involved in reproduction / positive regulation of odontogenesis of dentin-containing tooth / macrophage colony-stimulating factor receptor activity / forebrain neuron differentiation / CSF1-CSF1R complex / macrophage colony-stimulating factor signaling pathway / cell-cell junction maintenance / positive regulation of microglial cell migration / positive regulation of lymphocyte proliferation / regulation of macrophage migration / mammary duct terminal end bud growth / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / cellular response to macrophage colony-stimulating factor stimulus / negative regulation of myotube differentiation / organic cyclic compound binding / positive regulation of myoblast proliferation / positive regulation of cell cycle G1/S phase transition / microglial cell proliferation / positive regulation of macrophage differentiation / positive regulation of macrophage derived foam cell differentiation / positive regulation of mononuclear cell proliferation / olfactory bulb development / myeloid leukocyte migration / dentate gyrus development / positive regulation of leukocyte proliferation / positive regulation by host of viral process / positive regulation of mononuclear cell migration / neutrophil homeostasis / positive regulation of multicellular organism growth / ruffle organization / positive regulation of monocyte differentiation / positive regulation of osteoclast differentiation / microglia development / positive regulation of macrophage proliferation / positive regulation of Ras protein signal transduction / regulation of bone resorption / positive regulation of cell motility / branching involved in mammary gland duct morphogenesis / odontogenesis / positive regulation of leukocyte migration / positive regulation of cell-matrix adhesion / neuron projection extension / negative regulation of epithelial cell differentiation / positive regulation of macrophage chemotaxis / cytokine binding / growth factor binding / cellular response to cytokine stimulus / monocyte differentiation / regulation of MAPK cascade / macrophage differentiation / hemopoiesis / regulation of ossification / positive regulation of protein kinase activity / positive regulation of bone mineralization / positive regulation of chemokine production / positive regulation of tyrosine phosphorylation of STAT protein / homeostasis of number of cells within a tissue / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of protein metabolic process / transmembrane receptor protein tyrosine kinase activity / ossification / osteoclast differentiation / cytokine activity / response to ischemia / regulation of actin cytoskeleton organization / axon guidance / microglial cell activation / growth factor activity / receptor protein-tyrosine kinase / cytokine-mediated signaling pathway / peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / regulation of cell shape / cell body / perikaryon / protein phosphatase binding / protein tyrosine kinase activity / cell population proliferation / Ras protein signal transduction / protein autophosphorylation / membrane => GO:0016020 / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / receptor complex / nuclear body / positive regulation of cell migration Similarity search - Function Macrophage colony stimulating factor-1 / Macrophage colony stimulating factor-1 (CSF-1) / Macrophage colony-stimulating factor 1 receptor / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulin / Immunoglobulin domain ... Macrophage colony stimulating factor-1 / Macrophage colony stimulating factor-1 (CSF-1) / Macrophage colony-stimulating factor 1 receptor / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulin / Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homology Macrophage colony-stimulating factor 1 / Macrophage colony-stimulating factor 1 receptor / Macrophage colony-stimulating factor 1 Similarity search - ComponentBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.4 Å DetailsAuthors Chen, X. / Liu, H. / Focia, P.J. / Shim, A. / He, X. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2008Title : Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.Authors : Chen, X. / Liu, H. / Focia, P.J. / Shim, A.H. / He, X. History Deposition Sep 18, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 9, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_special_symmetry / pdbx_validate_chiral / pdbx_validate_symm_contact / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.occupancy / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_chiral.auth_asym_id / _pdbx_validate_chiral.auth_seq_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Aug 30, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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