登録情報 データベース : PDB / ID : 3eac 構造の表示 ダウンロードとリンクタイトル Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. 要素Tyrosine-protein kinase CSK 詳細 キーワード TRANSFERASE / SH2 / CSK / DISULFIDE / OXIDIZED / Reduced / ATP-binding / Cell membrane / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / SH2 domain / SH3 domain / Tyrosine-protein kinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of Golgi to plasma membrane protein transport / regulation of Fc receptor mediated stimulatory signaling pathway / negative regulation of low-density lipoprotein particle clearance / proline-rich region binding / adherens junction organization / negative regulation of bone resorption / negative regulation of phagocytosis / cellular response to peptide hormone stimulus / Phosphorylation of CD3 and TCR zeta chains / oligodendrocyte differentiation ... negative regulation of Golgi to plasma membrane protein transport / regulation of Fc receptor mediated stimulatory signaling pathway / negative regulation of low-density lipoprotein particle clearance / proline-rich region binding / adherens junction organization / negative regulation of bone resorption / negative regulation of phagocytosis / cellular response to peptide hormone stimulus / Phosphorylation of CD3 and TCR zeta chains / oligodendrocyte differentiation / protein kinase A catalytic subunit binding / negative regulation of interleukin-6 production / RHOH GTPase cycle / PD-1 signaling / GAB1 signalosome / Negative regulation of FLT3 / T cell costimulation / Integrin signaling / protein tyrosine kinase binding / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / negative regulation of ERK1 and ERK2 cascade / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / cell-cell junction / T cell receptor signaling pathway / protein phosphatase binding / protein tyrosine kinase activity / adaptive immune response / negative regulation of cell population proliferation / protein phosphorylation / extracellular exosome / ATP binding / identical protein binding / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 CSK-like, SH2 domain / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily ... CSK-like, SH2 domain / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.37 Å 詳細データ登録者 Liu, D. / Seidel, R.D. / Cowburn, D. 引用ジャーナル : Biophys Rep / 年 : 2016タイトル : Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.著者 : Liu, D. / Cowburn, D. 履歴 登録 2008年8月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2009年11月10日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2014年12月10日 Group : Version format compliance改定 1.3 2016年7月20日 Group : Database references改定 1.4 2016年12月14日 Group : Database references改定 1.5 2023年8月30日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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