登録情報 | データベース: PDB / ID: 2zpp |
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タイトル | Neutron crystal structure of cubic insulin at pD9 |
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要素 | - Insulin A chain
- Insulin B chain
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キーワード | HORMONE / CUBIC / PORCINE INSULIN / Carbohydrate metabolism / Cleavage on pair of basic residues / Glucose metabolism / Secreted |
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機能・相同性 | 機能・相同性情報
Insulin processing / IRS activation / Signal attenuation / Insulin receptor signalling cascade / Signaling by Insulin receptor / Synthesis, secretion, and deacylation of Ghrelin / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Insulin receptor recycling / glycoprotein biosynthetic process / response to L-arginine ...Insulin processing / IRS activation / Signal attenuation / Insulin receptor signalling cascade / Signaling by Insulin receptor / Synthesis, secretion, and deacylation of Ghrelin / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Insulin receptor recycling / glycoprotein biosynthetic process / response to L-arginine / positive regulation of lipoprotein lipase activity / lactate biosynthetic process / positive regulation of fatty acid biosynthetic process / positive regulation of glucose metabolic process / lipoprotein biosynthetic process / COPI-mediated anterograde transport / lipid biosynthetic process / negative regulation of gluconeogenesis / positive regulation of insulin receptor signaling pathway / positive regulation of protein autophosphorylation / positive regulation of DNA replication / positive regulation of protein secretion / insulin-like growth factor receptor binding / insulin receptor binding / hormone activity / glucose metabolic process / insulin receptor signaling pathway / glucose homeostasis / positive regulation of cell migration / extracellular space / identical protein binding類似検索 - 分子機能 Insulin / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Sus scrofa (ブタ) |
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手法 | 中性子回折 / NUCLEAR REACTOR / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Ishikawa, T. / Tanaka, I. / Niimura, N. |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2008 タイトル: An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis 著者: Ishikawa, T. / Chatake, T. / Morimoto, Y. / Maeda, M. / Kurihara, K. / Tanaka, I. / Niimura, N. |
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履歴 | 登録 | 2008年7月26日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2008年10月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.2 | 2013年8月21日 | Group: Other |
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改定 1.3 | 2018年3月7日 | Group: Data collection / カテゴリ: diffrn_detector / Item: _diffrn_detector.detector |
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改定 1.4 | 2023年11月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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