Entry Database : PDB / ID : 2ygg Structure visualization Downloads & linksTitle Complex of CaMBR and CaM ComponentsCALMODULIN SODIUM/HYDROGEN EXCHANGER 1 DetailsKeywords METAL BINDING PROTEIN/TRANSPORT PROTEIN / METAL BINDING PROTEIN-TRANSPORT PROTEIN COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential / cation-transporting ATPase complex / Sodium/Proton exchangers / regulation of the force of heart contraction by cardiac conduction / regulation of store-operated calcium channel activity / positive regulation of calcium:sodium antiporter activity / Hyaluronan uptake and degradation / regulation of cardiac muscle cell membrane potential / regulation of high voltage-gated calcium channel activity / cellular response to electrical stimulus ... sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential / cation-transporting ATPase complex / Sodium/Proton exchangers / regulation of the force of heart contraction by cardiac conduction / regulation of store-operated calcium channel activity / positive regulation of calcium:sodium antiporter activity / Hyaluronan uptake and degradation / regulation of cardiac muscle cell membrane potential / regulation of high voltage-gated calcium channel activity / cellular response to electrical stimulus / potassium:proton antiporter activity / : / sodium:proton antiporter activity / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / positive regulation of action potential / maintenance of cell polarity / : / positive regulation of calcineurin-NFAT signaling cascade / establishment of protein localization to mitochondrial membrane / regulation of pH / sodium ion export across plasma membrane / cellular response to acidic pH / cardiac muscle cell differentiation / type 3 metabotropic glutamate receptor binding / ion binding / sodium ion import across plasma membrane / protein phosphatase 2B binding / intracellular sodium ion homeostasis / cardiac muscle cell contraction / response to acidic pH / regulation of stress fiber assembly / establishment of protein localization to membrane / regulation of cardiac muscle contraction by calcium ion signaling / positive regulation of mitochondrial membrane permeability / regulation of synaptic vesicle endocytosis / cellular response to cold / cellular response to antibiotic / negative regulation of high voltage-gated calcium channel activity / regulation of focal adhesion assembly / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / positive regulation of cardiac muscle hypertrophy / protein phosphatase activator activity / positive regulation of the force of heart contraction / positive regulation of phosphoprotein phosphatase activity / cellular response to organic cyclic compound / adenylate cyclase binding / catalytic complex / intercalated disc / calcium channel regulator activity / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / calcium channel inhibitor activity / cellular response to interferon-beta / positive regulation of DNA binding / phosphatidylinositol 3-kinase binding / monoatomic ion transport / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / enzyme regulator activity / positive regulation of protein dephosphorylation / regulation of calcium-mediated signaling / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / potassium ion transmembrane transport / voltage-gated potassium channel complex / sperm midpiece / proton transmembrane transport / T-tubule / calcium channel complex / cellular response to epinephrine stimulus / response to amphetamine / activation of adenylate cyclase activity / response to muscle stretch / phosphatidylinositol-4,5-bisphosphate binding / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / positive regulation of nitric-oxide synthase activity / stem cell differentiation / calcium-mediated signaling / regulation of intracellular pH / positive regulation of receptor signaling pathway via JAK-STAT / spindle microtubule / phospholipid binding / spindle pole / cellular response to type II interferon / response to calcium ion Similarity search - Function Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2020 / Sodium/hydrogen exchanger 1-like / Sodium/hydrogen exchanger, regulatory region / Regulatory region of Na+/H+ exchanger NHE binds to calmodulin / Na+/H+ exchanger / Cation/H+ exchanger, CPA1 family / Cation/H+ exchanger / Sodium/hydrogen exchanger family / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / EF-hand domain pair ... Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2020 / Sodium/hydrogen exchanger 1-like / Sodium/hydrogen exchanger, regulatory region / Regulatory region of Na+/H+ exchanger NHE binds to calmodulin / Na+/H+ exchanger / Cation/H+ exchanger, CPA1 family / Cation/H+ exchanger / Sodium/hydrogen exchanger family / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / EF-hand domain pair / Helix non-globular / EF-hand, calcium binding motif / Special / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)RATTUS NORVEGICUS (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.227 Å DetailsAuthors Koester, S. / Yildiz, O. CitationJournal : J.Biol.Chem. / Year : 2011Title : Structure of Human Na+/H+ Exchanger Nhe1 Regulatory Region in Complex with Cam and Ca2+Authors : Koester, S. / Pavkov-Keller, T. / Kuehlbrandt, W. / Yildiz, O. History Deposition Apr 15, 2011 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 28, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Nov 30, 2011 Group : Database referencesRevision 1.2 Nov 19, 2014 Group : Data collectionRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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