登録情報 | データベース: PDB / ID: 1g4y |
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タイトル | 1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN |
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要素 | - CALCIUM-ACTIVATED POTASSIUM CHANNEL RSK2
- CALMODULIN
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キーワード | SIGNALING PROTEIN / small-conductance calcium-activated potassium channel / calmodulin / calmodulin binding domain (CaMBD) / channel gating |
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機能・相同性 | 機能・相同性情報
Ca2+ activated K+ channels / regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / small conductance calcium-activated potassium channel activity / : / membrane repolarization during atrial cardiac muscle cell action potential / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / calcium-activated potassium channel activity ...Ca2+ activated K+ channels / regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / small conductance calcium-activated potassium channel activity / : / membrane repolarization during atrial cardiac muscle cell action potential / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / calcium-activated potassium channel activity / : / : / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of ryanodine-sensitive calcium-release channel activity / : / positive regulation of potassium ion transport / inward rectifier potassium channel activity / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / establishment of protein localization to membrane / regulation of potassium ion transmembrane transport / positive regulation of DNA binding / negative regulation of high voltage-gated calcium channel activity / negative regulation of ryanodine-sensitive calcium-release channel activity / organelle localization by membrane tethering / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / negative regulation of calcium ion export across plasma membrane / regulation of cardiac muscle cell action potential / presynaptic endocytosis / nitric-oxide synthase binding / regulation of synaptic vesicle exocytosis / calcineurin-mediated signaling / alpha-actinin binding / regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / adenylate cyclase binding / catalytic complex / regulation of neuronal synaptic plasticity / regulation of synaptic vesicle endocytosis / detection of calcium ion / regulation of cardiac muscle contraction / postsynaptic cytosol / smooth endoplasmic reticulum / cellular response to interferon-beta / activation of adenylate cyclase activity / calcium channel inhibitor activity / presynaptic cytosol / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of nitric-oxide synthase activity / titin binding / enzyme regulator activity / sperm midpiece / regulation of calcium-mediated signaling / voltage-gated potassium channel complex / potassium ion transmembrane transport / calcium channel complex / T-tubule / response to amphetamine / regulation of heart rate / calyx of Held / nitric-oxide synthase regulator activity / adenylate cyclase activator activity / sarcomere / regulation of cytokinesis / protein serine/threonine kinase activator activity / spindle microtubule / calcium channel regulator activity / positive regulation of receptor signaling pathway via JAK-STAT / calcium-mediated signaling / sarcolemma / modulation of chemical synaptic transmission / potassium ion transport / cellular response to type II interferon / Schaffer collateral - CA1 synapse / Z disc / response to calcium ion / spindle pole / G2/M transition of mitotic cell cycle / calcium-dependent protein binding / disordered domain specific binding / myelin sheath / protein autophosphorylation / growth cone / vesicle / dendritic spine / transmembrane transporter binding / postsynaptic membrane / neuron projection / calmodulin binding / positive regulation of apoptotic process / protein domain specific binding / neuronal cell body / calcium ion binding / centrosome / protein kinase binding / glutamatergic synapse / cell surface / protein homodimerization activity類似検索 - 分子機能 Calmodulin-binding domain / Potassium channel, calcium-activated, SK / SK, calmodulin-binding domain superfamily / Calmodulin binding domain / Calcium-activated SK potassium channel / Calmodulin binding domain / Helix Hairpins - #70 / Potassium channel domain / Ion channel / EF-hand ...Calmodulin-binding domain / Potassium channel, calcium-activated, SK / SK, calmodulin-binding domain superfamily / Calmodulin binding domain / Calcium-activated SK potassium channel / Calmodulin binding domain / Helix Hairpins - #70 / Potassium channel domain / Ion channel / EF-hand / : / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Helix Hairpins / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Calmodulin-1 / Calmodulin-1 / Small conductance calcium-activated potassium channel protein 2類似検索 - 構成要素 |
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生物種 |  Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 多重同系置換 / 解像度: 1.6 Å |
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データ登録者 | Schumacher, M.A. / Rivard, A. / Bachinger, H.P. / Adelman, J.P. |
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引用 | ジャーナル: Nature / 年: 2001 タイトル: Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. 著者: Schumacher, M.A. / Rivard, A.F. / Bachinger, H.P. / Adelman, J.P. |
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履歴 | 登録 | 2001年1月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2001年5月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Derived calculations / Version format compliance |
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改定 1.3 | 2011年11月16日 | Group: Atomic model |
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改定 1.4 | 2024年2月7日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.5 | 2024年4月3日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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