登録情報 データベース : PDB / ID : 2x11 構造の表示 ダウンロードとリンクタイトル Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain 要素EPHRIN TYPE-A RECEPTOR 2 EPHRIN-A5 詳細キーワード RECEPTOR/SIGNALING PROTEIN / RECEPTOR-SIGNALING PROTEIN COMPLEX / DEVELOPMENTAL PROTEIN / SIGNALING PLATFORM / KINASE / TRANSFERASE / NEUROGENESIS / RECEPTOR / CATARACT / APOPTOSIS / ERYTHROPOIETIN-PRODUCING HEPATOCELLULAR CARCINOMA / ANGIOGENESIS / SIGNALING PROTEIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
neurotrophin TRKC receptor binding / neurotrophin TRKB receptor binding / negative regulation of substrate adhesion-dependent cell spreading / notochord cell development / notochord formation / synaptic membrane adhesion / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation ... neurotrophin TRKC receptor binding / neurotrophin TRKB receptor binding / negative regulation of substrate adhesion-dependent cell spreading / notochord cell development / notochord formation / synaptic membrane adhesion / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation / collateral sprouting / pericyte cell differentiation / positive regulation of collateral sprouting / cAMP metabolic process / cellular response to follicle-stimulating hormone stimulus / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration / regulation of insulin secretion involved in cellular response to glucose stimulus / ephrin receptor activity / leading edge membrane / negative regulation of chemokine production / neurotrophin TRKA receptor binding / post-anal tail morphogenesis / chemorepellent activity / bone remodeling / response to growth factor / activation of GTPase activity / regulation of cell morphogenesis / tight junction / regulation of lamellipodium assembly / positive regulation of synapse assembly / branching involved in mammary gland duct morphogenesis / EPH-Ephrin signaling / neural tube development / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / mammary gland epithelial cell proliferation / regulation of focal adhesion assembly / RHOV GTPase cycle / regulation of GTPase activity / retinal ganglion cell axon guidance / EPHA-mediated growth cone collapse / transmembrane receptor protein tyrosine kinase activator activity / growth factor binding / regulation of cell-cell adhesion / regulation of cell adhesion mediated by integrin / lamellipodium membrane / RHOU GTPase cycle / basement membrane / RHOG GTPase cycle / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / RAC2 GTPase cycle / RAC3 GTPase cycle / vasculogenesis / regulation of angiogenesis / regulation of microtubule cytoskeleton organization / GABA-ergic synapse / cellular response to forskolin / keratinocyte differentiation / RAC1 GTPase cycle / ephrin receptor binding / transmembrane receptor protein tyrosine kinase activity / regulation of ERK1 and ERK2 cascade / negative regulation of angiogenesis / osteoclast differentiation / cell chemotaxis / axon guidance / skeletal system development / molecular function activator activity / protein localization to plasma membrane / cell motility / regulation of actin cytoskeleton organization / positive regulation of protein localization to plasma membrane / adherens junction / receptor protein-tyrosine kinase / caveola / neuron differentiation / ruffle membrane / intrinsic apoptotic signaling pathway in response to DNA damage / osteoblast differentiation / positive regulation of peptidyl-tyrosine phosphorylation / cell migration / lamellipodium / virus receptor activity / nervous system development / receptor complex / cell adhesion / defense response to Gram-positive bacterium / positive regulation of cell migration / inflammatory response / cadherin binding / positive regulation of protein phosphorylation / external side of plasma membrane / focal adhesion / cell surface / ATP binding / plasma membrane 類似検索 - 分子機能 Ephrin-A ectodomain / Ephrin receptor-binding domain / Ephrin, conserved site / Ephrin / Ephrin / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Ephrin type-A receptor 2, ligand binding domain / Ephrin receptor type-A /type-B / : ... Ephrin-A ectodomain / Ephrin receptor-binding domain / Ephrin, conserved site / Ephrin / Ephrin / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Ephrin type-A receptor 2, ligand binding domain / Ephrin receptor type-A /type-B / : / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Growth factor receptor cysteine-rich domain superfamily / Fibronectin type III domain / Cupredoxin / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 4.83 Å 詳細データ登録者 Seiradake, E. / Harlos, K. / Sutton, G. / Aricescu, A.R. / Jones, E.Y. 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2010タイトル : An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly著者 : Seiradake, E. / Harlos, K. / Sutton, G. / Aricescu, A.R. / Jones, E.Y. 履歴 登録 2009年12月21日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2010年3月16日 Provider : repository / タイプ : Initial release改定 1.1 2011年8月31日 Group : Database references / Derived calculations ... Database references / Derived calculations / Refinement description / Version format compliance 改定 1.2 2018年2月28日 Group : Source and taxonomy / カテゴリ : entity_src_genItem : _entity_src_gen.gene_src_common_name / _entity_src_gen.host_org_common_name ... _entity_src_gen.gene_src_common_name / _entity_src_gen.host_org_common_name / _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_variant 改定 1.3 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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