Entry Database : PDB / ID : 1shw Structure visualization Downloads & linksTitle EphB2 / EphrinA5 Complex Structure ComponentsEphrin type-B receptor 2 Ephrin-A5 DetailsKeywords hormone/growth factor/receptor / receptor tyrosine kinase / ephrin signaling / hormone-growth factor-receptor COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
neurotrophin TRKB receptor binding / regulation of T-helper 17 type immune response / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / Ephrin signaling / negative regulation of NMDA glutamate receptor activity / EPH-Ephrin signaling / hindbrain tangential cell migration / EPHA-mediated growth cone collapse / vesicle-mediated intercellular transport / EPH-ephrin mediated repulsion of cells ... neurotrophin TRKB receptor binding / regulation of T-helper 17 type immune response / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / Ephrin signaling / negative regulation of NMDA glutamate receptor activity / EPH-Ephrin signaling / hindbrain tangential cell migration / EPHA-mediated growth cone collapse / vesicle-mediated intercellular transport / EPH-ephrin mediated repulsion of cells / EPHB-mediated forward signaling / positive regulation of NMDA glutamate receptor activity / regulation of body fluid levels / urogenital system development / optic nerve morphogenesis / tight junction assembly / postsynaptic membrane assembly / neuron projection retraction / negative regulation of substrate adhesion-dependent cell spreading / ephrin receptor activity / axon guidance receptor activity / regulation of cell-cell adhesion / central nervous system projection neuron axonogenesis / negative regulation of axonogenesis / synaptic membrane adhesion / positive regulation of long-term neuronal synaptic plasticity / regulation of autophagosome assembly / cellular response to follicle-stimulating hormone stimulus / collateral sprouting / positive regulation of dendritic spine morphogenesis / dendritic spine development / positive regulation of synaptic plasticity / positive regulation of collateral sprouting / corpus callosum development / regulation of filopodium assembly / camera-type eye morphogenesis / regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of behavioral fear response / chemorepellent activity / transmembrane-ephrin receptor activity / commissural neuron axon guidance / positive regulation of protein localization to cell surface / negative regulation of cell adhesion / dendritic spine morphogenesis / negative regulation of Ras protein signal transduction / regulation of cell morphogenesis / axonal fasciculation / positive regulation of synapse assembly / regulation of receptor signaling pathway via JAK-STAT / positive regulation of immunoglobulin production / regulation of synapse assembly / regulation of focal adhesion assembly / inner ear morphogenesis / regulation of axonogenesis / retinal ganglion cell axon guidance / regulation of GTPase activity / B cell activation / roof of mouth development / regulation of neuronal synaptic plasticity / regulation of blood coagulation / basement membrane / negative regulation of cytokine production involved in inflammatory response / GABA-ergic synapse / ephrin receptor signaling pathway / regulation of microtubule cytoskeleton organization / positive regulation of B cell proliferation / cellular response to forskolin / cell surface receptor protein tyrosine kinase signaling pathway / ephrin receptor binding / hippocampal mossy fiber to CA3 synapse / axonogenesis / negative regulation of protein phosphorylation / learning / positive regulation of long-term synaptic potentiation / caveola / cell periphery / regulation of actin cytoskeleton organization / positive regulation of protein localization to plasma membrane / adherens junction / animal organ morphogenesis / axon guidance / negative regulation of protein kinase activity / cell morphogenesis / receptor protein-tyrosine kinase / negative regulation of ERK1 and ERK2 cascade / peptidyl-tyrosine phosphorylation / cellular response to amyloid-beta / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / presynaptic membrane / signaling receptor activity / amyloid-beta binding / postsynapse / cellular response to lipopolysaccharide / postsynaptic membrane / protein tyrosine kinase activity / angiogenesis / dendritic spine / learning or memory / positive regulation of cell migration Similarity search - Function Ephrin type-B receptor 2, ligand binding domain / Ephrin-A ectodomain / Ephrin receptor-binding domain / Ephrin, conserved site / Ephrin / Ephrin / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like ... Ephrin type-B receptor 2, ligand binding domain / Ephrin-A ectodomain / Ephrin receptor-binding domain / Ephrin, conserved site / Ephrin / Ephrin / Ephrin receptor-binding (ephrin RBD) domain signature. / Ephrin receptor-binding (ephrin RBD) domain profile. / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / Galactose-binding domain-like / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Cupredoxins - blue copper proteins / Sterile alpha motif/pointed domain superfamily / Growth factor receptor cysteine-rich domain superfamily / Fibronectin type III domain / Cupredoxin / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Jelly Rolls / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Himanen, J.P. / Chumley, M.J. / Lackmann, M. / Li, C. / Barton, W.A. / Jeffrey, P.D. / Vearing, C. / Geleick, D. / Feldheim, D.A. / Boyd, A.W. CitationJournal : Nat.Neurosci. / Year : 2004Title : Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signalingAuthors : Himanen, J.P. / Chumley, M.J. / Lackmann, M. / Li, C. / Barton, W.A. / Jeffrey, P.D. / Vearing, C. / Geleick, D. / Feldheim, D.A. / Boyd, A.W. / Henkemeyer, M. / Nikolov, D.B. History Deposition Feb 26, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 18, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_residues / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Apr 3, 2024 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_residues Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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