Entry Database : PDB / ID : 3gc9 Structure visualization Downloads & linksTitle The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor ComponentsMitogen-activated protein kinase 11 Details Keywords TRANSFERASE / Serine/Threonine kinase / drug design / selectivity / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinaseFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of cardiac muscle cell proliferation / stress-activated protein kinase signaling cascade / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cardiac muscle cell proliferation / KSRP (KHSRP) binds and destabilizes mRNA / DSCAM interactions / cellular response to UV-B / positive regulation of muscle cell differentiation / Myogenesis / Activation of the AP-1 family of transcription factors ... negative regulation of cardiac muscle cell proliferation / stress-activated protein kinase signaling cascade / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cardiac muscle cell proliferation / KSRP (KHSRP) binds and destabilizes mRNA / DSCAM interactions / cellular response to UV-B / positive regulation of muscle cell differentiation / Myogenesis / Activation of the AP-1 family of transcription factors / ERK/MAPK targets / p38MAPK cascade / RHO GTPases Activate NADPH Oxidases / MAP kinase activity / mitogen-activated protein kinase / cellular response to interleukin-1 / stress-activated MAPK cascade / p38MAPK events / positive regulation of interleukin-12 production / activated TAK1 mediates p38 MAPK activation / NOD1/2 Signaling Pathway / bone development / cellular response to virus / VEGFA-VEGFR2 Pathway / osteoblast differentiation / cellular senescence / Oxidative Stress Induced Senescence / Regulation of TP53 Activity through Phosphorylation / intracellular signal transduction / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of gene expression / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ... Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution : 2.05 Å DetailsAuthors Scapin, G. / Patel, S.B. CitationJournal : Acta Crystallogr.,Sect.D / Year : 2009Title : The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.Authors : Patel, S.B. / Cameron, P.M. / O'Keefe, S.J. / Frantz-Wattley, B. / Thompson, J. / O'Neill, E.A. / Tennis, T. / Liu, L. / Becker, J.W. / Scapin, G. History Deposition Feb 21, 2009 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 21, 2009 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Refinement description / Version format complianceRevision 1.2 Mar 21, 2012 Group : Database referencesRevision 1.3 Jul 24, 2019 Group : Data collection / Refinement description / Category : softwareItem : _software.classification / _software.name / _software.versionRevision 1.4 Oct 20, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.5 Sep 6, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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